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Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors |
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| Authors: | Norbert Krautenbacher Michael Kabesch Elisabeth Horak Charlotte Braun-Fahrländer Jon Genuneit Andrzej Boznanski Erika von Mutius Fabian Theis Christiane Fuchs Markus J. Ege the GABRIELA PASTURE study groups |
| Affiliation: | 1. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (lead), Methodology (equal), Software (lead), Validation (lead), Visualization (lead), Writing - original draft (supporting), Writing - review & editing (equal);2. University Children’s Hospital Regensburg (KUNO), Regensburg, Germany;3. Department of Pediatrics and Adolescents, Innsbruck Medical University, Innsbruck, Austria Contribution: Conceptualization (equal), Investigation (equal), Project administration (equal), Resources (equal), Writing - review & editing (equal);4. Swiss Tropical and Public Health Institute Basel, Basel, Switzerland University of Basel, Basel, Switzerland Contribution: Conceptualization (equal), Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (equal), Writing - review & editing (equal);5. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany;6. Wroclaw Medical University, Wroclaw, Poland Contribution: Funding acquisition (equal), Investigation (equal), Methodology (equal), Project administration (equal), Resources (equal), Writing - review & editing (equal);7. The German Center for Lung Research (DZL), Germany Dr von Hauner Children’s Hospital, LMU Munich, Munich, Germany Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Asthma and Allergy Prevention, Neuherberg, Germany Contribution: Conceptualization (equal), Funding acquisition (lead), Investigation (equal), Methodology (equal), Project administration (lead), Resources (equal), Writing - review & editing (equal);8. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany Contribution: Methodology (equal), Resources (equal), Supervision (equal), Writing - review & editing (equal);9. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany Department of Business Administration and Economics, Bielefeld University, Bielefeld, Germany Contribution: Conceptualization (lead), Formal analysis (lead), Funding acquisition (equal), Investigation (equal), Methodology (lead), Software (lead), Supervision (lead), Validation (lead), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal);10. The German Center for Lung Research (DZL), Germany |
| Abstract: | |
| Keywords: | childhood asthma environment farming genome-wide association studies machine learning penalized regression random forest risk prediction single-nucleotide polymorphisms statistical learning |