| 前列腺癌错配修复基因蛋白MLH1缺失的研究 |
| |
| 引用本文： | 王剑松,赵庆华,等.前列腺癌错配修复基因蛋白MLH1缺失的研究[J].云南医药,2002,23(3):169-171. |
| |
| 作者姓名： | 王剑松 赵庆华 |
| |
| 作者单位： | [1]昆明医学院第二附属医院泌尿外科 [2]妇科，云南昆明650101 |
| |
| 摘 要： | 目的 探讨错配修复基因（MMR）蛋白MLH1在前列腺癌细胞株及前列腺癌标本的表达及其意义。方法 利用Western印迹法检测了前列腺癌细胞株中错配修复基因蛋白的丢失情况；用免疫组织化学法检测前列腺癌标本中错配修复蛋白的表达。结果 在所研究的8个前列腺癌细胞株中均发现有错配修复基因的缺失；前列腺癌标本中也存在错配修复蛋白MLH1表达的减少或消失。结论 前列腺癌中存在错配修复基因的缺失，错配修复基因的缺失直接参与了前列腺癌的发生与发展。
|
| 关 键 词： | 错配修复基因 MMR MLH1 遗传学 前列腺癌 |
Expression of mismatch repair gene MLH1 in prostate cancer. |
| |
| WANG Jiansong,ZHAO Qinghua,YIAN Chen,et al..Expression of mismatch repair gene MLH1 in prostate cancer.[J].Medicine and Pharmacy of Yunnan,2002,23(3):169-171. |
| |
| Authors: | WANG Jiansong ZHAO Qinghua YIAN Chen |
| |
| Institution: | WANG Jiansong,ZHAO Qinghua,YIAN Chen,et al. Department of Urology and Gynecology of the Second Affiliated Hospital of Kunming Medical College,Kunming |
| |
| Abstract: | Objective To explore the expression and role of mismatch repair(MMR)protein MLH1 in prostate cell-lines and human prostate cancer specimens.Methods Using Western bolt analysed,we detected the loss of MLH1 in prostate cell-lines.We also immunohistochemically analysed the expression of MLH1 in human prostate cancer specimens.Results We found the loss of MMR in all prostate cell-lines and the deduction or absence of MLH1's expressions in human prostate cancer specimens.Conclusions There are defects in human prostate cancer,which influence the origination and development of prostate cancer. |
| |
| Keywords: | MMR MLH1 Genetics Prostate cancer |
| 本文献已被 CNKI 维普 等数据库收录！ |
