| 5-氰基异苯并呋喃-1-酮的合成 |
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| 引用本文： | 刘丹,孟艳秋.5-氰基异苯并呋喃-1-酮的合成[J].中国医药工业杂志,2004,35(6):330-330,344. |
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| 作者姓名： | 刘丹 孟艳秋 |
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| 作者单位： | 沈阳化工学院制药工程系,辽宁,沈阳,110142 |
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| 摘 要： | 邻苯二甲酰亚胺经硝化、还原制得4-氨基邻苯二甲酰亚胺,还原1个羰基后加热脱氨并环合制得5-氨基异苯并呋喃-1-酮,最后经Sandmeyer反应进行氰基取代制得5-氰基异苯并呋喃-1-酮,总收率39%.
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| 关 键 词： | 5-氰基异苯并呋喃-1-酮 西酞普兰 中间体 合成 |
| 文章编号： | 1001-8255(2004)06-0330-01 |
Synthesis of 5-Cyanoisobenzofuran-1-one |
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| Authors: | LIU Dan MENG Yan-Qiu |
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| Abstract: | Cyanoisobenzofuran-1-one, a key intermediate of citalopram, was synthesized from phthalimide vianitration, reduction, carbonyl reduction, ammonia elimination and cyclization to give 5-aminoisobenzofuran-1-one followedby Sandmeyer reaction of cyano group replacement with an overall yield of 39%. |
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| Keywords: | cyanoisobenzofuran-1-one citalopram intermediate synthesis |
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