White-matter changes in early and late stages of mild cognitive impairment |
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| Institution: | 1. Graduate School of Health Sciences, Istanbul University, 34126, Fatih-Istanbul, Turkey;2. Department of Psychology, Faculty of Social Sciences, Beykoz University, 34810, Beykoz-Istanbul, Turkey;3. Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093, Capa-Istanbul, Turkey;4. Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093, Capa-Istanbul, Turkey;5. Department of Psychology, Faculty of Arts and Science, Isik University, 34980, Sile-Istanbul, Turkey;6. Department of Psychology, Faculty of Arts and Science, Yeditepe University, 34755, Atasehir-Istanbul, Turkey;7. Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 34093, Capa-Istanbul, Turkey;1. Department of Neurosurgery, Stanford University, Stanford, CA, United States;2. Department of Neurosurgery, University Hospital Zurich & Clinical Neuroscience Center, University of Zurich, Switzerland;3. Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, United States;4. Department of Pathology, Stanford University, Stanford, CA, United States;1. Depatment of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;2. Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;3. Department of Neuroscience, Neurosurgery Section, Università Cattolica del Sacro Cuore, Rome, Italy;1. Radiology Department, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia;2. Faculty of Medicine, Dentistry, and Health Sciences at the University of Melbourne, Parkville, Melbourne, Victoria, Australia;1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY, USA;2. Department of Radiology, Albany Medical College, Albany, NY, USA;1. Department of Psychiatry, Istanbul University Istanbul Faculty of Medicine, ?stanbul, Turkey;2. Hulusi Behcet Life Sciences Research Laboratory, Istanbul University, Turkey;3. Private Practice, Turkey;4. Department of Radiology, Neuroradiology Division, Istanbul University Istanbul Faculty of Medicine, ?stanbul, Turkey |
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| Abstract: | Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer’s Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions. |
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| Keywords: | Mild cognitive impairment Dementia White-matter hyperintensities Episodic memory Hippocampus |
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