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Adoptive T cell therapy: Boosting the immune system to fight cancer |
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| Affiliation: | 1. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;3. Department of Immunology and Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;4. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States;5. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States |
| Abstract: | Cellular therapies have shown increasing promise as a cancer treatment. Encouraging results against hematologic malignancies are paving the way to move into solid tumors. In this review, we will focus on T-cell therapies starting from tumor infiltrating lymphocytes (TILs) to optimized T-cell receptor-modified (TCR) cells and chimeric antigen receptor-modified T cells (CAR-Ts). We will discuss the positive preclinical and clinical findings of these approaches, along with some of the persisting barriers that need to be overcome to improve outcomes. |
| Keywords: | CAR-T cells T-cell receptor-modified (TCR) cells Cytolytic T cells (CTLs) Tumor infiltrating T cells (TILs) Adoptive cell therapy Hematologic malignancies |
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