A pediatric case of anaplastic astrocytoma with a gliomatosis cerebri; the growth pattern and changes in serum VEGF-121 levels after bevacizumab treatment |
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| Institution: | 1. Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1, Yanagido, Gifu, Gifu 501 1194, Japan;2. Department of Pediatrics, Matsunami General Hospital, 185-1, Tashiro, Hashima-gun, Gifu 501 6062, Japan;3. Department of Radiology, Gihoku Kousei Hospital, 1187-3, Takatomi, Yamagata, Gifu 501 2105, Japan;4. Department of Neurosurgery, Graduate School of Medicine, Gifu University, 1-1, Yanagido, Gifu, Gifu 501 1194, Japan;5. Department of Radiology, Graduate School of Medicine, Gifu University, 1-1, Yanagido, Gifu, Gifu 501 1194, Japan;1. Department of Surgery, Teikyo University, Tokyo, Japan;2. Department of Cardiovascular and Thoracic Surgery, the 4th Affiliated Hospital of Harbin Medical University, Harbin, China;3. Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan;4. Department of Dermatology, Huashan Hospital of Fudan University, Shanghai, China;1. Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China;2. Department of Paediatrics, The Second Staff Hospital of Wuhan Iron and Steel Group Corporation, Wuhan, Hubei Province, China;1. Allergy Immunology Unit Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India;2. Department of Oral Health Sciences, Postgraduate Institute of Medical Education and Research, Chandigarh, India;3. Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;4. Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India;5. Department of Anesthesia, Postgraduate Institute of Medical Education and Research, Chandigarh, India;6. Department of Clinical Immunology, University College Hospitals, London and Addenbrooke’s Hospital, Cambridge, UK;1. Department of Pediatrics, Georgetown University School of Medicine, 4431, Albemarle St NW, 20016 Washington DC, USA;3. Departments of Audiology and Speech, Walter Reed National Military Medical Center, Bethesda-Maryland, USA;4. Department of Otolaryngology, Walter Reed National Military Medical Center, Bethesda-Maryland, USA;1. Medical-Surgical Research Center, University of Cartagena, Cartagena, Colombia;2. Neurosurgeon-Critical Care, Biomedical Research Center, University of Cartagena, Cartagena de Indias, Colombia;3. Department of Neurosurgery, All India Institute of Medical Sciences, India |
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| Abstract: | Gliomatosis cerebri (GC) is a rare diffusely infiltrating glial neoplasm that carries a poor prognosis. Because tumors are undetectable in most patients at early-stage of the onset, a useful diagnostic method is expected. We compared serum vascular endothelial growth factor (VEGF)-121 levels in patients with GC or glioblastoma and controls. VEGF-121 levels were significantly higher in one patient with GC and patients with glioblastoma than in controls. VEGF-121 levels decreased in a patient with GC after bevacizumab-based therapy. Thus, VEGF-121 may be useful for diagnosing GC, its disease-monitoring and understanding its etiology. |
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| Keywords: | Brain neoplasms Glioma Glioblastoma Temozolomide |
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