Genomic annotation and molecular evolution of monkeypox virus outbreak in 2022 |
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| Authors: | Lulan Wang Jingzhe Shang Shenghui Weng Saba R. Aliyari Chengyang Ji Genhong Cheng Aiping Wu |
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| Affiliation: | 1. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA;2. Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China;3. Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
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| Abstract: | Monkeypox virus (MPXV) has generally circulated in West and Central Africa since its emergence. Recently, sporadic MPXV infections in several nonendemic countries have attracted widespread attention. Here, we conducted a systematic analysis of the recent outbreak of MPXV-2022, including its genomic annotation and molecular evolution. The phylogenetic analysis indicated that the MPXV-2022 strains belong to the same lineage of the MPXV strain isolated in 2018. However, compared with the MPXV strain in 2018, in total 46 new consensus mutations were observed in the MPXV-2022 strains, including 24 nonsynonymous mutations. By assigning mutations to 187 proteins encoded by the MPXV genome, we found that 10 proteins in the MPXV are more prone to mutation, including D2L-like, OPG023, OPG047, OPG071, OPG105, OPG109, A27L-like, OPG153, OPG188, and OPG210 proteins. In the MPXV-2022 strains, four and three nucleotide substitutions are observed in OPG105 and OPG210, respectively. Overall, our studies illustrated the genome evolution of the ongoing MPXV outbreak and pointed out novel mutations as a reference for further studies. |
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| Keywords: | molecular evolution monkeypox MPXV endemic orthopoxvirus |
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