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Calcifying pseudoneoplasm of the neuroaxis presenting with refractory seizures: Case report and literature review
Affiliation:1. Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA;2. Department of Neurological Surgery, San Francisco University of Quito School of Medicine, Quito, Ecuador;3. Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA;1. Department of Neurological Surgery, University of California San Francisco, United States;2. Department of Neuropathology, University of California San Francisco, United States;1. Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan;2. Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan;3. Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan;1. Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany;2. Department of Neuropathology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany;1. Neuroradiology Department, Hospital de Braga, Sete Fontes – São Victor, 4710-243 Braga, Portugal;2. Neurology Department, Hospital de Braga, Sete Fontes – São Victor, 4710-243 Braga, Portugal;1. Department of Neurosurgery, The Canberra Hospital, Garran, ACT, Australia;2. Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia;1. Division of Neurosurgery, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia;2. Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA;3. Fralin Biomedical Research Institute, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA
Abstract:Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare benign lesions that can arise anywhere within the central nervous system. The etiology of these lesions remains unknown and diagnosis is made on pathohistological analysis. We present the case of a 35-year-old male patient with a history of epilepsy since childhood who was evaluated for refractory seizures. MRI revealed a small lesion in the left-posterior temporal lobe suspected to be a cavernoma. A gross total resection of the lesion was achieved via a left temporal craniotomy and pathological analysis revealed CAPNON. At 6 months follow-up, the patient remained neurologically intact and his seizures had ceased.
Keywords:Calcifying pseudoneoplasm of the neuroaxis  CAPNON  Seizures  Epilepsy  Cavernoma
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