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Hand-foot syndrome induced changes of the palmar epidermal ridge configurations during and after treatment with capecitabine
Affiliation:1. Institute of Legal Medicine, University Hospital Düsseldorf, Germany;2. University of Applied Sciences for Public Administration and Management Northrhine-Westphalia, Hagen, Germany;3. Department of Gastroenterology, Hepatology, and Infectious Dieseases, University Hospital Düsseldorf, Germany;4. Department of Gastroenterology, Hepatology, Diabetology, and Nutritional Medicine, Petrus Hospital Wuppertal, Germany;1. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts;2. Department of Cardiac Surgery, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts;3. Division of Hematology, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts;1. Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland;2. Kyiv National Taras Shevchenko University, Department of Chemistry, Volodymyrska str. 64, 01601 Kyiv, Ukraine;3. Institute Light Matter, UMR5306 CNRS-UCB Lyon 1, University of Lyon, 69622 Villeurbanne, France;4. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wrocław, Poland;1. Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan;2. Ishiwata Orthodontic Clinic, Kanagawa, Japan;3. Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, Nigata, Japan;4. Department of Orthodontics, Tokyo Dental College, Chiba, Japan;5. Our Lady of Snow Social Medical Corporation St. Mary’s Hospital Orthodontic Department, Fukuoka, Japan;6. Department of Oral and Maxillofacial Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan;7. Division of Orthodontics, Department of Oral Science, Kanagawa Dental University, Kanagawa, Japan;8. Department of Oral-Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Hospital, Tokyo, Japan;9. Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;1. Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland;2. Radioactivity Environment Remediation (RER) Consultants, Fuchsbauerweg 50, 94036 Passau, Germany
Abstract:Palmar plantar erythrodysesthesia (hand-foot syndrome, HFS) is a common adverse event of treatment with cytostatic chemotherapeutics such as capecitabine. Histopathological findings are nonspecific and may even include generalized epidermal necrolysis.A total of 50 patients were examined before and after the intake of capecitabine to assess if HFS may result in relevant changes of the palmar epidermal ridge configurations with possible consequences for the patients who want to travel abroad.In total, 14 of the 50 patients developed HFS (28%) with HFS grades 1–3 observed. HFS grade 4 was not observed.HFS of grade 2 and 3 was associated with a temporary macroscopic loss of the epidermal ridges. No dactyloscopic changes that might have led to a false identification were seen in those cases.Patients with a risk of HFS development who want to travel abroad should carry a medical pass of the chemotherapeutic treatment to prevent them from difficulties in identification controls.
Keywords:Hand-foot syndrome  Palmar plantar erythrodysesthesia  Epidermal ridges  Fingerprints  Travel  Identification
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