| 自组装药物传递系统 |
| |
| 引用本文： | 金义光. 自组装药物传递系统[J]. 国际药学研究杂志, 2010, 37(3): 165-169,186 |
| |
| 作者姓名： | 金义光 |
| |
| 作者单位： | 军事医学科学院放射与辐射医学研究所七室,北京,100850 |
| |
| 基金项目： | 国家重大新药创制科技重大专项--综合性新药研究开发技术大平台资助项目 |
| |
| 摘 要： | 自组装药物传递系统（SADDS）是基于药质体提出的新概念和新给药系统,融合了前药、分子自组装和纳米技术,是两亲前药形成的自组装纳米体系。其突出的特点是自组装体几乎没有辅料的参与,载药量大,稳定性好,在体内可获得靶向、控释效果,特别适合于抗病毒和抗肿瘤治疗。SADDS是学科交叉的产物,是药剂学研究的新方向。本文阐述了SADDS概念的来源、特点和研究进展,并展望了SADDS的研究前景。
|
| 关 键 词： | 前药 自组装 纳米技术 自组装药物传递系统 药质体 靶向制剂 |
| 收稿时间： | 2010-05-14 |
| 修稿时间： | 2010-05-28 |
Self-assembled drug delivery system |
| |
| JIN Yi-guang. Self-assembled drug delivery system[J]. Foreign Medical Sciences(Section of Pharmarcy), 2010, 37(3): 165-169,186 |
| |
| Authors: | JIN Yi-guang |
| |
| Affiliation: | （Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China） |
| |
| Abstract: | Self-assembled drug delivery system(SADDS) is a novel concept and a novel drug delivery system based on pharmacosomes. It integrates prodrug, molecular self-assembly and nanotechnology and can be defined as the nanosized self-assembled system formed from amphiphilic prodrugs. Its outstanding advantages include: a) the self-assemblies composed of prodrugs without excipients; b) high drug loads; c) strong stability; and d) in vivo targeting and controlled release. It can be applied to antiviral and anticancer therapy. SADDS is an inter-disciplinary product representing the latest progress in pharmaceutics. This paper describes the concept resource, characteristics and research progress in SADDS and analyzes the prospective of SADDS. |
| |
| Keywords: | prodrug self-assembly nanotechnology self-assembled drug delivery systems pharmacosomes targeted drug delivery systems |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《国际药学研究杂志》浏览原始摘要信息 |
|
点击此处可从《国际药学研究杂志》下载全文 |
|
