血清YKL—40和CA125联合检测在卵巢癌诊断中的应用

目的探讨血清YKL-40和CA125联合检测在卵巢癌诊断中的应用价值。方法分别用酶免分析法(EIA)和微粒子酶免分析法(MEIA)测定39例卵巢癌、27例卵巢良性肿瘤及40例健康对照妇女血清YKL-40和CA125水平,YKL-40以健康对照组95%可信区间的上限值为阳性,比较YKL-40和CA125在三组间、卵巢癌病人不同临床分期和手术治疗前后水平和阳性率的差异。结果正常对照组血清YKL-40水平的95%可信区间的上限值为71.9ng/mL;卵巢癌患者血清YKL-40水平及阳性率显著高于卵巢良性肿瘤组和对照组(t>4.83,P<0.01),而卵巢良性肿瘤组和对照组之间差异无统计学意义(t=0.96,P>0.05)。Ⅲ/Ⅳ期卵巢癌患者血清YKL-40水平显著高于Ⅰ/Ⅱ期患者(167.9ng/mLvs87.7ng/mL,t=1.86,P<0.01)。卵巢癌患者术后第3天和第7天血清YKL-40水平显著低于术前水平(t>2.92,P<0.01);未能手术切除的患者血清YKL-40水平显著高于手术切除者(t=4.06,P<0.01)。YKL-40联合CA125诊断卵巢癌的灵敏度为87.2%,特异性为91.0%,阳性...

Clinical Value of Combined Detection of Serum YKL-40 and CA125 in Epithelial Ovarian Cancer Patients

Objective To investigate the clinical value of combined detection of serum YKL-40 and CA125 in patients with epithelial ovarian cancer(EOC).Methods 40 healthy subjects(27 patients with benign gynecologic processes and 39 preoperative patients diagnosed with EOC) enrolled in the Baoan people' hospital between 2004 year and 2006 year were studied.The levels of YKL-40 were assayed by enzyme immunoassay(EIA).Micropartical enzyme immunoassay(MEIA) was used to detect serum CA125 expression.YKL-40 value beyond the...