抗精神病药引起女性闭经的调查

目的了解女性患者服用抗精神病药后出现闭经的情况。方法对入院后的女性精神分裂症患者进行观察,对四种药物用药前及用药后四周血清泌乳素(PRL),和四种药物所致闭经的构成比做统计分析。结果2004年10月至2006年3月共观察女性病人408例,根据所服抗精神病药不同分成四组,四组患者服药后四周PRL明显升高。四种药物所致闭经的构成比如下:氯丙嗪(104例)27.88%;利培酮(118例)34.75%;奥氮平(96例)21.88%;奎硫平(90例)11.11%。结论抗精神病药所致闭经是常见副反应,在本次调查中,四种抗精神病药用药后四周PRL较用药前升高明显,在用药过程中出现闭经的比例均在10.00%以上,其中以氯丙嗪、利培酮为高。

The survey of amenorrhea in the female psychiatric patients taking antipsychotics

Objective:To observe the occurrence rate of amenorrhea in female schizophrenia patients after taking antipsychotic drugs.Methods:408 in-patients in Shanghai Mental Health Center(10/2004~3/2006)were enrolled in this study.They were treated with four different types of antipsychotic drugs.Collect the data of the schizophrenia patients with self made questionnaire before and after drugs taken for 4 weeks,compare the occurrence rate of amenorrhea and prolactin(PRL)level in serum of the patients among different drug groups with statistical method.Results:The total 408 patients were divided into 4 groups according to the different drugs taken.The prolactin level in serum were consistly raised in the four different drug groups,the occurrence rate of menorrhea in each drug group revealed by our observation are listed as follows:chlorpromazine(n=104)27.88%,risperidone(n=118)34.75%,olanzapine(n=96)21.88%,qutiepine(n=90)11.11%.Conclusion:Amenorrhea is the common side effects of antipsychotic drugs.In our study,the prolactin level in the serum were all raised higher after using antipsychotic drugs in 4 weeks,the average amenorrhea rates of amenorrhea in the four drug groups are all above 10%.Among them,chlorpromazine and risperidone ranks much more higher.