Varicella-zoster viral meningitis mimicking lymphoma |
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Authors: | Park S Leymarie V Agbalika F Galicier L Oksenhendler E Sigaux F Noguera M E |
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Institution: | Laboratoire d'hématologie, H?pital Saint-Louis, 1 av Claude Vellefaux, 75010 Paris, France. parksophie@yahoo.com |
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Abstract: | We report the case of a 30-year-old HIV-infected man admitted for a meningeal syndrome and a zoster rash. The CSF had cytological features suggesting a primary CNS lymphoma (PCNSL). The large lymphoid cells had a fine chromatin with nucleoli, a basophilic cytoplasm with azurophilic granules and high mitotic activity. Several arguments demonstrated the viral origin of the meningitis: the large lymphoid cells were of T origin with no evidence of clonal TCR γ gene rearrangement. The PCR was positive for Varicella-Zoster Virus (VZV) and EBV DNA. Clinical evolution was favorable under acyclovir. We should be cautious in the differential diagnosis between viral meningitis and PCNSL. |
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Keywords: | Varicella-Zoster Virus Meningitis Lymphoma Pcr |
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