Increased Isolation and Characterization of Shigella sonnei Obtained from Hospitalized Children in Tehran, Iran |
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| Authors: | Reza Ranjbar Mohammad M. Soltan Dallal Malihe Talebi Mohammad R. Pourshafie |
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| Affiliation: | 1 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2 Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Science;3 Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran |
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| Abstract: | Shigella flexneri has been the most frequent cause of shigellosis in children in Iran. To evaluate the changes in frequency of serogroups, 302 Shigella species were isolated in 2003 from hospitalized children, aged less than 12 years, with acute diarrhoea in Tehran, Iran. The number of collected S. sonnei, S. flexneri, S. boydii, and S. dysenteriae isolates was 178 (58.9%), 110 (37.4%), 10 (3.3%), and 4 (1.3%) respectively. Most (94%) S. sonnei isolates were resistant to co-trimoxazole. They were, however, relatively or completely sensitive to 15 commonly-used antibiotics. The extracted plasmids showed 12 different profiles with two closely-related patterns constituting 70% of the total isolates. Ribotyping, using PvuII, HindIII or SalI restriction enzymes, generated a single pattern for all S. sonnei isolates. Data suggest that S. sonnei has become the predominant serogroup in children in the hospitals of Tehran.Key words: Antibiotic resistance, Antibiotics, Drug resistance, Microbial, Dysentery, Bacillary, Ribotyping, Shigella sonnei, Iran |
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