Nonopioid nature of the pressor effect of FMRF-amide |
| |
| Authors: | R. L. Tinyakov S. B. Parin N. A. Sokolova I. P. Ashmarin |
| |
| Affiliation: | (1) Laboratory of Pathological Physiology, Nizhni Novgorod Institute of Traumatology and Orthopedics, Moscow, USSR;(2) Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, USSR |
| |
| Abstract: | The effect of the peptide FMRFa on arterial pressure, heart rate, and respiratory rate is examined in anesthetized rats. It is demonstrated that the effect of FMRFa is similar to that of epinephrine and is characterized by transient hypertension against the background of bradycardia and decreased respiratory rate followed by hypotensive phase. Opiate antagonists and agonists do not modify the effect of FMRFa. Pressor effect of FMRFa is inhibited by Aminazine and is abolished by dihydroergotamine, while clopheline, reserpine, propranolol, Dimedrol, and adrenalectomy have no appreciable effect on it. It is suggested that the effects of FMRFa are realized via vascular adrenoreceptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 513–515, November, 1997 |
| |
| Keywords: | FMRFa opioids hypertension adrenoreceptors |
| 本文献已被 SpringerLink 等数据库收录！ |
|
