| 乙型肝炎病毒与丙型肝炎病毒重叠感染重症化探讨 |
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| 引用本文： | 刘道洁,刘芳,谢贤春,谢立.乙型肝炎病毒与丙型肝炎病毒重叠感染重症化探讨[J].医学理论与实践,2006,19(12):1385-1386. |
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| 作者姓名： | 刘道洁 刘芳 谢贤春 谢立 |
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| 作者单位： | 首都医科大学附属北京佑安医院,北京市卫生局肝炎研究所,北京,100069 |
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| 摘 要： | 目的:探讨HBV、HCV重叠感染时,病毒之间的相互关系及对病情转归的影响。方法:用ELISA法检测180例患者乙肝病毒血清学指标(HBV-M)和丙肝病毒抗体(抗-HCV),用PCR和RT-PCR体外扩增法检测HBV-DNA和HCV-RNA。结果:HBV、HCV重叠感染LC和HCC的发生率远远高于单纯HBV或HCV感染,HBV、HCV重叠感染患者中HBV-DNA和HBsAg的阳性率明显低于单纯HBV感染者。结论:HBV重叠感染HCV后,对肝细胞的损害加重,重叠感染患者病情的发展及转归可能主要与HCV有关,是HBV、HCV作用相互叠加的结果。
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| 关 键 词： | 乙型肝炎病毒 丙型肝炎病毒 重叠感染 |
| 文章编号： | 1001-7585（2006）12-1385-02 |
| 收稿时间： | 2006-06-12 |
| 修稿时间： | 2006年6月12日 |
Study of Severe Liver Disease in Patients Coinfected with HBV and HCV |
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| LIU Daojie, LIU Fang, XIE Xianchun,et al..Study of Severe Liver Disease in Patients Coinfected with HBV and HCV[J].The Journal of Medical Theory and Practice,2006,19(12):1385-1386. |
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| Authors: | LIU Daojie LIU Fang XIE Xianchun |
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| Institution: | Beijing Youan Hospital Affiliated to Capital University of Medical Sciences, Beijing 100069 |
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| Abstract: | Objective:To understand the results of dual infection by hepatitis B virus(HBV) and hepatitis C virus(HCV),and research preliminarily the viral interference between HBV and HCV infections.Methods: The biochemical and virologic markers of 180 patients were detected with ELISA. Among 180 patients tested,73 patients were only infected by HBV,65 patients were only infected by HCV and 42 patients were co-infected by HBV and HCV.Results:The positive rate of HBsAg and HBV-DNA in patients with co-infection was obviously lower than that of HBV infection only.Conclusion:The disease was more severe in patients with co-infection.The prevalence of LC and HCC in patients with co-infection was higher than that of either infection alone.HBV and HCV inhibit the replication with each other,but HCV seems to suppress HBV replication more evidently. |
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| Keywords: | Hepatitis B virus(HBV) Hepatitis C virus(HCV) Co-infection |
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