血管性痴呆患者血浆同型半胱氨酸监测的临床意义分析

目的:探讨血管性痴呆患者血浆中同型半胱氨酸含量测定的诊断及治疗意义。方法:选取收治的血管性痴呆患者263例,其中138例患者诊断为轻度血管性痴呆,64例患者诊断为中度血管性痴呆,61例患者诊断为重度血管性痴呆,选取同时期的门诊健康体检者100例作为对照组,测定上述患者的血浆同型半胱氨酸浓度。结果:轻度、中度以及重度血管性痴呆患者的血浆Hcy浓度呈上升趋势,其简易精神智能状态评分呈下降趋势,且这种差异具有统计学意义(P<0.05);轻度、中度、重度血管性痴呆患者的血浆Hcy及其简易精神智能状态评分和平均值与对照组相比,差异具有统计学意义(P<0.05)。结论:血浆中同型半胱氨酸水平是血管性痴呆发生的独立危险因素之一,对于血管性痴呆的诊断及治疗都有着重要的临床意义。

The Clinical Research of Plasma Homocysteine Levels in Vascular Dementia

Objective To investigate the significance of plasma homocystetine （Hcy） level for diagnose and theapy of vascular dementia. Method To select 263 cases of vascular dementia who was treated, 138 of them were mild, 64 of them were moderate, and 61 of them were severe. 100 cases of healthy subject were selected as normal controls. The plasma Hcy levels were determined. Results The plasma Hey levels in mild, moderate, severe vascular dementia group appeared to be rising, but the score of Mini - Mental State Examination （MMSE） appeared to be declining, and the difference was statistically significant（ P 〈 0. 05 ）. Compared to the normal controls , the plasma Hcy levels, the score of MMSE and the average of both were significantly different （ P 〈 0.05 ）. Conclusion The plasma Hcy levels is one of the independent risk factors for vascular dementia. The determination of the plasma Hey levels is significant for the diagnose and theapy of vascular dementia.