纳洛酮对急重症脑梗死的疗效观察

目的探讨纳洛酮对急重症脑梗死患者的临床疗效。方法回顾性分析2009年1月-2014年1月期间在本院住院治疗的80例急重症脑梗死患者,其中40例患者给予常规的抗血小板、抗凝等治疗（对照组）,而另40例患者在常规治疗基础上给予纳洛酮治疗（观察组）,对比两组患者的治疗效果。结果对照组基本痊愈8例,显效13例,有效6例,无效13例,总有效率67.5%;观察组患者基本痊愈13例,显效15例,有效7例,无效5例,总有效率87.5%,两组对比差异有统计学意义（P〈0.05）。结论纳洛酮应用于急重症脑梗死患者的治疗中,能够和常规治疗起协同作用,提高治疗效果,值得临床推广。

Clinical effect observation on naloxone in the treatment of severe cerebral infarction

Objective To discuss the clinical effect of naloxone in the treatment of severe cerebral infarction.Methods 80 patients with severe cerebral infarction treated in our hospital during January 2009 to January 2014 were retrospectively analyzed. Among them, 40 cases were treated with routine antiplatelet and anticoagulation treatment （control group）, while the other 40 cases were treated with naloxone on basis of routine treatment. Clinical effects of the 2 groups were compared.Results In control group, there were 8 cases cured, 13 cases with significant effect, 6 cases with effect and 13 cases without effect, and the total effective rate was 67.5%; in observation group, there were 13 cases cured, 15 cases with significant effect, 7 cases with effect and 5 cases without effect, and the total effective rate was 87.5% （P〈0.05）.Conclusion Naloxone has a synergistic effect with routine treatment in treatment of patients with severe cerebral infarction. It can improve clinical effect and it is worth of clinical promotion.