Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect |
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Authors: | Hiroki Kato Masayuki Kanematsu Osamu Tanaka Keisuke Mizuta Mitsuhiro Aoki Toshiyuki Shibata Tomomi Yamashita Yoshinobu Hirose Hiroaki Hoshi |
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Institution: | (1) Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501–1194, Japan;(2) High-level Imaging Diagnosis Center, Gifu University Hospital, 1-1 Yanagido, Gifu 501–1194, Japan;(3) Department of Otolaryngology, Gifu University School of Medicine, Gifu, Japan;(4) Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan;(5) Department of Pathology, Gifu University School of Medicine, Gifu, Japan |
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Abstract: | The purpose of our study was to evaluate the usefulness of diffusion-weighted imaging in predicting the responses to neoadjuvant
therapy for head and neck squamous cell carcinomas. Diffusion-weighted, T2-weighted, and gadolinium-enhanced T1-weighted images
were obtained from 28 patients with untreated head and neck squamous cell carcinomas with histological proof. A blinded radiologist
evaluated the quantitative and qualitative signal intensities and apparent diffusion coefficients (ADCs) in the lesions on
each sequence. All patients were treated by neoadjuvant therapies, and the post-therapeutic tumor regression rate was determined.
Both the quantitative and qualitative signal intensities on diffusion-weighted images showed positive correlations (r = 0.367 and 0.412, p < .05), and the ADCs showed a weak, inversed correlation (r = −0.384, p < .05) with the tumor regression rates. Diffusion-weighted imaging including an assessment by ADCs may be able to predict
tumor response to neoadjuvant therapy for head and neck squamous cell carcinomas. |
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Keywords: | Diffusion-weighted imaging Squamous cell carcinoma Head and neck Neoadjuvant therapy |
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