血清及房水中VEGF、IL-6水平与新生血管性青光眼的相关性研究

目的测定新生血管性青光眼（NVG）患者血清及房水中血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）的水平,探讨VEGF、IL-6在NVG发生发展中的作用。方法选取NVG患者20例（20只眼）作为实验组（A组）,原发性慢性闭角型青光眼患者（B组）、老年性白内障患者（C组）各20例（20只眼）作为对照组。采集3组患者血清及房水标本,通过双抗体夹心酶联免疫吸附试验（ELISA法）分别检测血清与房水中VEGF、IL-6的水平。结果 （1）A组房水中VEGF、IL-6的水平（1336.80±70.15）pg/ml、（691.15±50.09）pg/ml明显高于B组（311.60±31.06）pg/ml、（168.25±11.95）pg/ml和C组（165.75±13.95）pg/ml,（92.10±9.59）pg/ml,3组间两两比较,差异均具有统计学意义（F=4019.334,P〈0.01;F=2275.019,P〈0.01）。A组血清中VEGF、IL-6的水平（545.40±155.49）pg/ml、（291.35±22.66）pg/ml高于B组（321.15±52.57）pg/ml、（104.35±13.21）pg/ml和C组（176.30±20.38）pg/ml、（87.00±12.70）pg/ml,3组间两两比较,差异均具有统计学意义（F=75.940,P〈0.01;F=906.947,P〈0.01）。（2）A组房水中VEGF与IL-6的水平呈显著的正相关性,差异具有统计学意义（r=0.857,P〈0.01）。其余各组标本中无显著的相关性（P〉0.05）。结论 NVG患者房水及血清中VEGF、IL-6的水平明显高于对照组,且房水中二者水平呈明显正相关,提示在NVG病理机制过程中,VEGF、IL-6作为促血管生成因子,相互促进、相互影响,共同导致了NVG的发生和发展。

Study of the correlation between serum,aqueous humor VEGF,IL-6 levels and the neovascular glaucoma

Objective This study was designed to discuss the role of VEGF,IL-6 in the development of NVG,by detecting the NVG serum and aqueous humor VEGF and IL-6 levels.Methods 20 patients with NVG were selected as experimental group(group A),20 patients with primary chronic angle closure glaucoma patients(group B),and 20 cases of senile cataract patients(group C) as a control group.three specimens of serum and aqueous humor were collected and the serum and aqueous humor VEGF,IL-6 levels were measured through the dou...