替吉奥联合顺铂治疗进展期胃癌的近期疗效观察

目的　观察国产替吉奥（Ｓ-１）联合顺铂一线治疗进展期胃癌的近期疗效及安全性。方法　４８例进展期胃癌患者分为治疗组和对照组，各２４例。治疗组方案为：Ｓ-１４０～６０ｍｇｂｉｄｄ１～ｄ２１；顺铂６０ｍｇ／ｍ２静滴，ｄ８，５周为１周期。对照组方案为：多西紫杉醇７５ｍｇ／ｍ２静滴，ｄ１；顺铂２０ｍｇ／ｍ２静滴，ｄ１～ｄ３；亚叶酸钙２０ｍｇ／ｍ２静滴，ｄ１ ～ｄ５；氟尿嘧啶３５０ｍｇ／ｍ２ 微量泵持续２４ｈ静滴，ｄ１～ｄ５，３周为１周期。３个周期后评价两组疗效及不良反应。结果　４８例患者均可评价疗效和不良反应，治疗组和对照组的有效率分别为５８.３％和５４.２％，差异无统计学意义（Ｐ＞０.０５），但治疗组的临床获益率为８７.５％，优于对照组６２.５％，差异有统计学意义（Ｐ＜０.０５）；治疗组的不良反应及严重反应发生率均明显低于对照组。结论　Ｓ-１联合顺铂化疗方案一线治疗进展期胃癌的近期疗效较好，不良反应轻，值得临床进一步研究应用。

Short-term efficacy of homemade S-1 combined with cisplatin for advanced gastric carcinoma

Objective To evaluate the short-term efficacy and toxicity of the combination of S-1 and cisplatin in the treatment of patients with advanced gastric carcinoma.Methods Forty-eight patients with advanced gastric carcinoma were randomly divided into two groups with 24 cases in each group.Experimental group was treated by S-1(40-60mg bid d1-d21) combined with cisplatin(60mg/m2 iv d8) with 5 weeks as a cycle,while control group was treated by doxtaxol(75mg/m2 iv d1),cisplatin(20mg/m2 iv d1-d3),calcium folinate(...