| Fibulin3在结直肠癌中的表达及其预后意义 |
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| 引用本文： | 朱卉,焦南林,张有为,汪竹,童建东.Fibulin3在结直肠癌中的表达及其预后意义[J].临床肿瘤学杂志,2011,16(8):701-704. |
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| 作者姓名： | 朱卉 焦南林 张有为 汪竹 童建东 |
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| 作者单位： | 1 ２２５００９ 江苏扬州 扬州大学第二临床医学院扬州市第一人民医院肿瘤科
2 ２４１００１ 皖南医学院附属弋矶山医院病理科 |
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| 摘 要： | 目的 探讨Ｆｉｂｕｌｉｎ３在结直肠癌（ＣＲＣ）中的表达情况及其临床意义。方法 收集８５例ＣＲＣ患者术后癌组织及癌旁组织行免疫组化法检测Ｆｉｂｕｌｉｎ３蛋白的表达，并回顾性分析其与临床病理特征及总生存期（ＯＳ）、无进展生存（ＤＦＳ）的关系。结果 在８５例ＣＲＣ组织中，４９例（５７.６％）患者癌组织的Ｆｉｂｕｌｉｎ３蛋白呈低表达，３６例（４２.４％）呈高表达；而在相应的癌旁组织中，２４例（２８.２％）呈低表达，６１例（７１.８％）呈高表达，两者差异有统计学意义（Ｐ＜０.００１）。Ｆｉｂｕｌｉｎ３表达下调与临床分期（Ｐ＝０.０３５）及淋巴结转移（Ｐ＝０.０１１）相关；经生存分析和Ｃｏｘ风险比例回归模型显示，Ｆｉｂｕｌｉｎ３表达下调是ＯＳ及ＤＦＳ的独立预后指标。结论 Ｆｉｂｕｌｉｎ３表达失活可能在ＣＲＣ发生发展中起重要作用，并可作为ＣＲＣ预后的预测指标。
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| 关 键 词： | Fibulin3 免疫组化 结直肠癌 预后 |
| 收稿时间： | 2011-01-30 |
| 修稿时间： | 2011-03-26 |
Expression of fibulin3 protein in colorectal cancer and its clinical significance |
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| ZHU Hui,JIAO Nan-lin,ZHANG You-wei,WANG Zhu,TONG Jian-dong.Expression of fibulin3 protein in colorectal cancer and its clinical significance[J].Chinese Clinical Oncology,2011,16(8):701-704. |
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| Authors: | ZHU Hui JIAO Nan-lin ZHANG You-wei WANG Zhu TONG Jian-dong |
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| Institution: | ZHU Hui,JIAO Nan-lin,ZHANG You-wei,WANG Zhu,TONG Jian-dong.Department of Oncology,Yangzhou No.1 People's Hospital,the Second Clinical School of Yangzhou University,Yangzhou 225009,China |
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| Abstract: | Objective To explore the expression of fibulin3 protein in tissues of colorectal cancer(CRC) patients and its clinical significance.Methods A total of 85 paired CRC specimens and their adjacent normal tissues were collected.Fibulin3 protein expression was analyzed by immunohistochemical staining in 85 CRC patients,and its correlations with clinicopathological factors,overall survival(OS) and disease-free survival(DFS) were further evaluated.Results In 85 CRC patients,36 tumor tissues(42.4%) and 61 adjacent ... |
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| Keywords: | Fibulin3 Immunohistochemistry Colorectal cancer Prognosis |
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