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Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure |
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| Authors: | Peter Celec Július Hodosy Michal Behuliak Roland Pálffy Roman Gardlík Luká? Hal?ák Imrich Mucska |
| Affiliation: | 1. Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia 2. Institute of Pathophysiology, Comenius University, Bratislava, Slovakia 3. Department of Molecular Biology, Comenius University, Bratislava, Slovakia 4. Institute of Physiology, Comenius University, Bratislava, Slovakia 5. Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia 6. Institute of Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Bratislava, Slovakia 7. Sleep Laboratory, University Hospital, Comenius University, Bratislava, Slovakia |
| Abstract: | PurposeThe pathogenesis of cardiovascular complications of obstructive sleep apnea syndrome (OSAS) can be explained by oxidative and carbonyl stress due to oxygenation and reoxygenation injury during sleep. This hypothesis has yet to be proved experimentally, although several clinical observations have found increased oxidative damage in plasma. Continuous positive airway pressure (CPAP) improves symptoms and prognosis of patients with OSAS. |
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