| 舒尼替尼治疗伊马替尼治疗失败或不能耐受GIST的毒副反应及其防治 |
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| 引用本文： | 夏蕾,杨雪琴,王阁,王东,杨镇洲,杨利军.舒尼替尼治疗伊马替尼治疗失败或不能耐受GIST的毒副反应及其防治[J].临床肿瘤学杂志,2011,16(9):794-799. |
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| 作者姓名： | 夏蕾 杨雪琴 王阁 王东 杨镇洲 杨利军 |
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| 作者单位： | 1 ４０００４２ 重庆 第三军医大学大坪医院野战外科研究所肿瘤中心
2 ２０００４１ 上海辉瑞投资有限公司 |
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| 摘 要： | 目的 探讨舒尼替尼(索坦)治疗甲磺酸伊马替尼治疗失败或不能耐受的胃肠间质瘤(GIST)患者的毒副反应情况及其防治措施.方法2009年1月至201 1年1月索坦治疗甲磺酸伊马替尼治疗失败或不能耐受的GIST患者41例,其中男性24例,女性17例,平均年龄55.5岁(29～82岁).29例口服索坦50mg/日,5例口服索坦...
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| 关 键 词： | 舒尼替尼 伊马替尼 胃肠间质瘤 毒性 |
| 收稿时间： | 2011-06-27 |
| 修稿时间： | 2011-07-19 |
Sunitinib in treating imatinib-resistant or intolerant gastrointestinal stromal tumours(GIST):toxicity and management |
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| XIA Lei,YANG Xue-qin,WANG Ge,WANG Dong,YANG Zhen-zhou,YANG Li-jun.Sunitinib in treating imatinib-resistant or intolerant gastrointestinal stromal tumours(GIST):toxicity and management[J].Chinese Clinical Oncology,2011,16(9):794-799. |
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| Authors: | XIA Lei YANG Xue-qin WANG Ge WANG Dong YANG Zhen-zhou YANG Li-jun |
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| Institution: | XIA Lei,YANG Xue-qin,WANG Ge,WANG Dong,YANG Zhen-zhou,YANG Li-jun.Cancer Center,Field Surgical Research Institute,Daping Hospital,the Third Military Medical University,Chongqing 400042,China |
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| Abstract: | Objective To evaluate the characteristics of toxicities of sunitinib(sutent) in treating imatinib-resistant or intolerant gastrointestinal stromal tumours(GIST),and propose an effective algorithm for managing side effects in clinical practice.Methods Forty-one patients with imatinib-resistant or intolerant GIST were treated with sutent from Jan.2009 to Jan.2011.Twenty-four cases were male,17 were female.The average age was 55.5years(29-82 years).Single agent of sutent 50mg once daily was administrated to 29... |
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| Keywords: | Sunitinib Imatinib Gastrointestinal stromal tumor(GIST) Toxicity |
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