| BRAF分子检测在结直肠癌中的研究进展 |
| |
| 引用本文： | 谭清和,陈佳. BRAF分子检测在结直肠癌中的研究进展[J]. 临床肿瘤学杂志, 2011, 16(12): 1146-1149 |
| |
| 作者姓名： | 谭清和 陈佳 |
| |
| 作者单位： | ２２６３６１ 江苏南通 南通市肿瘤医院肿瘤内科 |
| |
| 摘 要： | 目的 结直肠癌经典化疗方案是以氟尿嘧啶为主的联合化疗.近年来,抗表皮生长因子受体(EGFR)的靶向治疗被广泛讨论,且在结直肠癌的治疗中取得一定疗效.目前,对抗EGFR靶向治疗的疗效研究已经涉及到相关基因的表达状态,如既往探讨较多的K-Ras基因表达,新近又发现BRAF基因的突变在结直肠癌的发展以及抗EGFR靶向药物的疗...
|
| 关 键 词： | BRAF 结直肠癌 抗EGFR靶向治疗 |
| 收稿时间： | 2011-04-10 |
| 修稿时间： | 2011-06-15 |
Research of BRAF-biomarker detection in colorectal cancer |
| |
| TAN Qing-he , CHEN Jia. Research of BRAF-biomarker detection in colorectal cancer[J]. Chinese Clinical Oncology, 2011, 16(12): 1146-1149 |
| |
| Authors: | TAN Qing-he CHEN Jia |
| |
| Affiliation: | TAN Qing-he,CHEN Jia. Department of Medical Oncology,Nantong Tumor Hospital,Nantong 226361,China |
| |
| Abstract: | Objective Fluoropyrimidine-based chemotherapy regimens are considered as standard treatment in colorectal cancer.The epidermal growth factor receptor(EGFR) represents an important target for cancer treatment.Despite the roll of K-Ras mutations in the targeted therapy of colorectal cancer,BRAF mutations have emerged as an important predictive marker in the development of colorectal cancer and efficacy in EGFR targeted therapy.This article aims to review the mechanism of BRAF gene in the development of colore... |
| |
| Keywords: | BRAF Colorectal cancer Anti-EGFR therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《临床肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《临床肿瘤学杂志》下载免费的PDF全文 |
