| 重组人粒细胞集落刺激因子治疗急性放射性口腔黏膜损伤的临床观察 |
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| 引用本文： | 冯静,林贵山,程惠华. 重组人粒细胞集落刺激因子治疗急性放射性口腔黏膜损伤的临床观察[J]. 临床肿瘤学杂志, 2011, 16(10): 923-925 |
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| 作者姓名： | 冯静 林贵山 程惠华 |
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| 作者单位： | ３５００２５ 福州 南京军区福州总医院放疗科 |
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| 摘 要： | 目的 观察重组人粒细胞集落刺激因子（ｒｈＧ-ＣＳＦ）对鼻咽癌急性放射性口腔黏膜损伤的作用。方法 将５０例鼻咽癌住院患者随机分为对照组和ｒｈＧ ＣＳＦ治疗组，每组２５例。对照组用生理盐水每次１０ｍｌ含漱，治疗组用生理盐水１００ｍｌ＋ｒｈＧ-ＣＳＦ９００μｇ溶液每次１０ｍｌ含漱；每日３～５次，每次１０分钟。两组均采用标准分割方式放疗，观察急性口腔黏膜损伤的发生率、严重程度及其疗效。结果 放疗２０Ｇｙ时治疗组的黏膜损伤发生率为４０％，对照组为６８％（Ｐ＝０.０４７）。放疗结束治疗组的１～４级黏膜损伤发生率分别为４４％、２４％、１２％和０，对照组分别为１６％、２８％、４４％和８％（Ｐ＜０.０５）。治疗组患者的生活质量各项指标均较对照组有明显改善（Ｐ＜０.０５）。结论 ｒｈＧ-ＣＳＦ能够降低鼻咽癌急性放射性黏膜损伤的发生率，并减轻其损伤程度，值得推广。
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| 关 键 词： | 重组人粒细胞集落刺激因子 鼻咽癌 急性放射性口腔黏膜损伤 |
| 收稿时间： | 2010-12-02 |
| 修稿时间： | 2011-04-09 |
Effect of recombinant human granulocyte colony-stimulating factor on acute radiation oral mucositis |
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| FENG Jing,LIN Gui-shan,CHENG Hui-hua. Effect of recombinant human granulocyte colony-stimulating factor on acute radiation oral mucositis[J]. Chinese Clinical Oncology, 2011, 16(10): 923-925 |
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| Authors: | FENG Jing LIN Gui-shan CHENG Hui-hua |
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| Affiliation: | FENG Jing,LIN Gui-shan,CHENG Hui-hua.Department of Radiotherapy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,China |
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| Abstract: | Objective To evaluate the effect of recombinant human granulocyte colony-stimulating factor(rhG-CSF)on acute oral mucositis of nasopharyngeal carcinoma.Methods Fifty cases of nasopharyngeal carcinoma patients were randomly divided into control group(25 cases)and treatment group by rhG-CSF(25 cases).The control group was treated by normal salne with gargling administration(10ml each time,3-5 times daily,10min for each gargling) and the treatment group was treated by mouth wash containing 100ml normal saline ... |
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| Keywords: | Recombinant human granulocyte colony-stimulating factor Nasopharyngeal carcinoma Acute radiation oral mucositis |
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