注射用盐酸头孢甲肟在5%转化糖注射剂中的稳定性

目的考察注射用盐酸头孢甲肟在5%转化糖注射剂中的稳定性。方法分别于25、37℃条件下,采用双波长分光光度法测定24 h内5%转化糖注射剂中盐酸头孢甲肟的含量,观察配伍液外观并测定pH值和微粒数。结果在25℃条件下,配伍液中盐酸头孢甲肟含量6 h内无明显变化,配伍液外观、pH值无明显变化,微粒数符合规定;但在37℃条件下,盐酸头孢甲肟含量4 h内下降19.43%,配伍液颜色加深,pH值有一定程度上升。结论 5%转化糖注射剂可以用作注射用盐酸头孢甲肟的稀释剂,但应注意环境温度对配伍液稳定性的影响。

Stability of cefmenoxime hydrochloride for injection in 5%invert sugar injection

AIM To observe the stability of cefmenoxime hydrochloride for injection in 5%invert sugar injection. METHODS The appearance of the mixed solution was observed,and the number of particles and pH values of the mixed solution were detected.The content of cefmenoxime hydrochlorid was determined by dual-wavelength spectrotometry at 25℃and 37℃within 24 h.RESULTS There were no significant content changes occurred in mixed solution for cefmenoxime hydrochloride 6 h at 25℃.The pH values,appearances and number of particles of mixed solution were no significant change as well.But at 37℃,the content of cefmenoxime hydrochlorid was observed a reduction by 19.43%.The pH values and appearances of mixed solution were significant change.CONCLUSION The 5%invert sugar injection can be used as a kind of dilution for cefmenoxime hydrochloride for injection at 25℃within 6 h,but special attention should be paid to the effect of temperature on mixed solution,especially in summer condition.