过敏性紫癜患儿尿蛋白和内皮素的临床关联研究

研究过敏性紫癜（HSP）、过敏性紫癜性肾炎（HSPN）患儿尿清蛋白与内皮素1（ET-1）在HSP、HSPN发生发展中的作用。对对照组（21例）和紫癜患儿（29例）,用磺柳酸比浊法测定尿清蛋白排泄率（UAER）,用放射免疫法（RIA）测定血清ET-1水平,比较UAER和ET-1在HSP与HSPN的水平变化以及在HSPN治疗前后的水平变化。HSP组与对照组24h尿清蛋白比较无显著差异（P〉0.05）,HSPN组与对照组、HSP组比较有非常显著差异（P〈0.01,）;ET-1在HSP组与对照组比较有显著差异（P〈0.05）;HSPN组与对照组、HSP组比较有非常显著差异和显著差异（P〈0.01,P〈0.05）;HSPN组治疗后24h尿清蛋白和ET-1降低,较治疗前有非常显著差异（P〈0.01）;24h尿清蛋白与血清ET-1呈正相关关系（r=0.504,P〈0.05）。ET-1参与HSP、HSPN的发病,并与尿蛋白的发生、发展有关。

Relationship Between Urine Albumin and Endothelin in Children with Anaphylactoid Purpura

To study the function of urine albumin and endothelin（ET-1） in the occurrence and progress of ansphylactoid purura（HSP） and anaphylaxis purura nephritis（HSPN） in children,the serum level of ET-1 and urine albumin excretion rate in 29 children with HSP and 21 normal controls was detected by RIA and salicylic acid nephelometry respectively.The results showed that the content of urine albumin in 24 hours in HSP group has no significant difference compared with that of control group（P〉0.05）,but the corresponding content in HSPN group has significant difference compared with that of control and HSP group（P〈0.01）.The serum ET-1 in HSP group has significant difference compared with control group（P〈0.05）,and the corresponding content in HSPN group has significant difference compared with control group and HSP group（P〈0.01,P〈0.05）.The levels of urine albumin of 24 hours and serum ET-1 in HSPN group after treatment were decreased obviously compared with those before treatment（P〈0.01）.The content of urine albumin of 24 hours was positively correlated with serum levels of ET-1.The ET-1 participated the formation of HSP and HSPN,and was related to the occurrence and progress of urine albumin.