| 槲皮黄素灌胃后大鼠肝静脉血浆代谢组学的变化及其意义 |
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| 引用本文： | 安代志,张琪,韦京豫,杨继军,颜贤忠,郭长江.槲皮黄素灌胃后大鼠肝静脉血浆代谢组学的变化及其意义[J].肠外与肠内营养,2010,17(2). |
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| 作者姓名： | 安代志 张琪 韦京豫 杨继军 颜贤忠 郭长江 |
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| 作者单位： | 1. 军事医学科学院卫生学环境医学研究所,天津,300050
2. 国家生物医学分析中心,北京,100850 |
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| 基金项目： | 国家自然科学基金资助项目(30571567) |
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| 摘 要： | 目的:研究槲皮黄素灌胃后对大鼠肝静脉血浆代谢组学的变化及其意义。方法:大鼠按40mg/kg剂量槲皮黄素灌胃,分别于灌胃前(0h)、灌胃后0.5、1、2和4h采集肝静脉血液制备血浆,以1H核磁共振(1H NMR)分析代谢组变化。结果:槲皮黄素灌胃后,大鼠肝静脉血浆代谢组呈聚类分布,葡萄糖含量下降,β-羟丁酸、琥珀酸和丙酮酸等水平升高。结论:槲皮黄素对大鼠肝代谢具有显著影响,主要表现为葡萄糖分解增强,酮体生成增加。
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| 关 键 词： | 槲皮黄素 代谢组学 核磁共振 |
Analysis of metabonomic changes of hepatic vein plasma after oral administration of quercetin in rats |
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| AN Dai-zhi,ZHANG Qi,WEI Jing-yu,YANG Ji-jun,YAN Xian-zhong,GUO Chang-jiang.Analysis of metabonomic changes of hepatic vein plasma after oral administration of quercetin in rats[J].Parenteral & Enteral Nutrition,2010,17(2). |
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| Authors: | AN Dai-zhi ZHANG Qi WEI Jing-yu YANG Ji-jun YAN Xian-zhong GUO Chang-jiang |
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| Institution: | 1.Institute of Hygiene and Environmental Medicine;Tianjin 300050;China;2.National Center of Biomedical Analysis;Beijing 100850;China |
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| Abstract: | Objective: To investigate the effects of quercetin on hepatic vein metabolic profiles in rats. Methods: Male Wistar rats were administrated orally with 40 mg/kg quercetin. Hepatic vein plasma was collected at 0 h, 0.5 h, 1 h, 2 h and 4 h respectively after administration and analyzed by 1H NMR. Results: The identifiable biochemical effects associated with quercetin dosing included decreased plasma concentration of glucose and increased plasma concentration of succinate,β-hydroxybutyrate and pyruvate. Conclusion: Quercetin changes hepatic metabolism in rats, manifested mainly as increased glucose catabolism and production of ketone bodies. |
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| Keywords: | Quercetin Metabonomics Nuclear magnetic resonance |
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