老年原发性高血压患者外周血淋巴细胞亚群及活化状态的研究

目的：探讨老年原发性高血压患者外周血淋巴细胞亚群活化状态变化。方法采用流式细胞术检测65岁以上老年原发性高血压患者（观察组）170例和体检健康者（对照组）50例外周血淋巴细胞亚群以及活化状态。结果观察组B淋巴细胞表达的 CD3-CD19＋高于对照组，T 淋巴细胞活化表达的 CD3＋CD8＋CD38＋高于对照组,CD3＋HLA- DR＋, CD3＋CD8＋HLA- DR＋以及NK细胞表达的CD16＋CD56＋高于对照组（均P＜0.05）。T淋巴细胞表达的CD3＋低于对照组（均P＜0.05）。T细胞亚群表达的CD3＋CD4＋、CD3＋CD8＋比例下降,调节性T细胞CD3＋CD4＋CD25＋比例上升，但与对照组比较差异无统计学意义（均P＞0.05）。结论老年原发性高血压患者B淋巴细胞、NK淋巴细胞和CD8＋T细胞的活化能力显著增加。

The study of activation state of peripheral lymphocyte subsets in elder with essential hypertension

Objective To investigate the activation state of peripheral lymphocyte subsets in elder with essential hypertension. Methods Peripheral lymphocyte subsets and activation state were analyzed by flow cytometry in 170 elder with essential hypertension and 50 healthy people. Results The expressions of CD3-CD19＋ of B lymphocyte, CD3＋CD8＋CD38＋ of T lymphocyte, CD3＋HLA- DR＋, CD3＋CD8＋HLA- DR＋ and CD16＋CD56＋ of NK cel were significantly higher in elder with hypertension than in healthy person （al P〈0.05）. The CD3＋CD8＋,CD3＋CD4＋and CD3＋CD4＋CD25＋of T lymphocyte were not different between them （al P〉0.05）. Conclusion The activation of B lymphocyte cel , NK cel and CD8＋T lymphocyte increases in elder with hypertension.