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玉屏风颗粒调理气虚体质反复感冒患者临床观察
引用本文:陈聪,王琦,苏泽琦,彭莉,李佳林,王停. 玉屏风颗粒调理气虚体质反复感冒患者临床观察[J]. 中国实验方剂学杂志, 2018, 24(5): 182-187
作者姓名:陈聪  王琦  苏泽琦  彭莉  李佳林  王停
作者单位:北京中医药大学 中医体质与生殖中心, 北京 100029,北京中医药大学 中医体质与生殖中心, 北京 100029,北京中医药大学 北京中医药研究院, 北京 100029,北京中医药大学 中医体质与生殖中心, 北京 100029,北京中医药大学 中医体质与生殖中心, 北京 100029,北京中医药大学 北京中医药研究院, 北京 100029
摘    要:目的:观察玉屏风颗粒防治反复感冒及调理气虚体质的临床疗效。方法:采用多中心、随机、对照研究的方法,将符合方案的229例气虚体质受试者分为观察组174例,对照组55例;观察组给予玉屏风颗粒,对照组给予玉屏风颗粒安慰剂,疗程均为3个月,随访周期1年,分别在给药前、给药后3,6,9,12个月观察临床疗效。结果:试验完成情况良好,基线可比。治疗后观察组反复感冒次数低于对照组(P0.05),观察组气虚体质临床表现总积分低于对照组(P0.05),总积分减分率为49.82%,各临床表现积分减分率均高于对照组。两组服用玉屏风颗粒3个疗程停药后,观察组首次出现感冒时间相较于对照组明显延长(P0.05);不同时点观察组气虚体质总积分显著低于对照组(P0.01)。结论:玉屏风颗粒可有效减少气虚质反复感冒次数,对感冒再次发生具有一定预防作用,并可改善气虚体质。

关 键 词:玉屏风颗粒  气虚体质  反复感冒  临床研究
收稿时间:2017-07-04

Clinical Trial of Yupingfeng Granules in Recuperation of Qi-deficient Constitution with Recurrent Common Cold
CHEN Cong,WANG Qi,SU Ze-qi,PENG Li,LI Jia-lin and WANG Ting. Clinical Trial of Yupingfeng Granules in Recuperation of Qi-deficient Constitution with Recurrent Common Cold[J]. China Journal of Experimental Traditional Medical Formulae, 2018, 24(5): 182-187
Authors:CHEN Cong  WANG Qi  SU Ze-qi  PENG Li  LI Jia-lin  WANG Ting
Affiliation:Research of Centre of Traditional Chinese Medicine Constitution and Reproductive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Research of Centre of Traditional Chinese Medicine Constitution and Reproductive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Research of Centre of Traditional Chinese Medicine Constitution and Reproductive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Research of Centre of Traditional Chinese Medicine Constitution and Reproductive Medicine, Beijing University of Chinese Medicine, Beijing 100029, China and Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Abstract:Objective:To observe the clinical efficacy of Yupingfeng granules in preventing and treating the recurrent common cold and recuperating the Qi-deficient constitution. Method:A total of 229 subjects with Qi-deficient constitution were recruited in this trial and randomly divide into treatment group (174 cases) and control group (55 cases). The subjects in treatment group orally took Yupingfeng granules, while the subjects in control group took Yupingfeng granules placebo. Each group was treated for 3 months, and the follow-up period was 1 year. Clinical efficacy was observed before treatment, 3, 6, 9, 12 months after treatment. Result:The study was finished well with a comparable baseline. The number of the recurrent common cold in treatment group was lower than that in control group after treatment (P<0.05); the total score of clinical features of the Qi-deficient constitution in treatment group was lower than that in control group (P<0.05), and the reductive ratio of total score in treatment group was 49.82%, and each of the reductive ratio of clinical features in treatment group was higher than that in control group. After 3 treatment courses, the appearance of the first time of colds in treatment group was significantly expanded as compared with control group (P<0.05), and the scores of clinical features of the Qi-deficient constitution in treatment group were significant lower than those in control group at different time points (P<0.01) Conclusion:Yupingfeng granules can effectively reduce the numbers of the recurrent common cold of the Qi-deficient constitution, with some preventive effect on recurrence of colds and recuperate the Qi-deficient constitution.
Keywords:Yupingfeng granules  Qi-deficient constitution  recurrent common cold  clinical trial
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