糖耐量减低人群颈动脉内膜中层厚度与血清学指标相关性研究

目的:了解糖耐量减低(IGT)人群颈动脉内膜中层厚度(IMT)与血清学指标相关性。方法:行标准75g葡萄糖耐量试验(OGTT),将108例IGT患者作为IGT组,120例糖耐量正常(NGT)体检者作为NGT组,采用彩色多普勒超声检查仪行颈动脉彩超检查,比较各组IMT水平;按IMT是否增厚将IGT组分为IMT正常组、增厚组,采用全自动生化分析仪测指标浓度;对各组年龄、血压、体质量指数(BMI)、血糖(FBG)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清尿酸(UA)、高敏C反应蛋白(CRP)、空腹血清胰岛素(FINS),计算稳态模型胰岛素抵抗指数(HOMA-IR)等临床资料与血清学指标进行比较分析。结果:IGT组FBG、2hPG、LDL-C、CRP、FINS、HOMA-IR、OGTT、IMT均高于NGT组;IMT增厚组平均年龄、BMI、2hPG、LDL-C、FINS、HOMA-IR、OGTT均高于IMT正常组,差别均有统计学意义,经多元回归分析IGT患者平均年龄、BMI、2hPG、LDL-C、FINS、HOMA-IR、OGTT均与IGT患者颈动脉IMT厚度相关。结论:平均年龄、BMI、2hPG、LDL-C、FINS、HOMA-IR、OGTT均是IGT人群IMT增厚的密切相关因素。

Study on the correlation between carotid intima-media thickness and serum markers of people with impaired glucose tolerance

Objective: To study the correlation between carotid intima-media thickness and serum markers in people with impaired glucose tolerance(IGT).Methods: 108 IGT patients were taken as the IGT group and 120 cases of normal glucose tolerance persons(NGT) were taken as NGT group.In 75g OGTT, advanced doppler ultrasound instrument was used for carotid ultrasonography to detect the IMT levels of both groups.The IGT group was divided into normal IMT group and thickening IMT group by the standard whether IMT thicken,then the concentration of serum markers were determined with the automatic biochemical analyzer. Age,blood pressure,body mass index(BMI),blood glucose(FBG),serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),serum uric acid(UA),high-sensitivity C-reactive protein(CRP) and fasting serum insulin(FINS),calculated homeostasis model insulin resistance index(HOMA-IR) and other clinical data were taken to compare with serological indicators. Results: FBG,2hPG,LDL-C,CRP,FINS,HOMA-IR,OGTT and IMT values of IGT group were higher than those of NGT group.Avg age,BMI,2hPG,LDL-C,FINS,HOMA-IR and OGTT values of thickening IMT group were higher than those of normal IMT group.The differences were statistically significant.Within the multiple regression analysis, patients′ avg age,IGT,BMI,2hPG,LDL-C,FINS,HOMA-IR and OGTT values were all related to IMT incrassation in IGT patients.Conclusion: Avg age,BMI,2hPG,LDL-C,FINS,HOMA-IR and OGTT values are all close indicators of IMT incrassation in IGT patients.