| 丙戊酸钠与经典抗心律失常药作用的比较 |
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| 引用本文： | 贾宏钧,刘馨,严幼芳,叶雨文. 丙戊酸钠与经典抗心律失常药作用的比较[J]. 中南大学学报(医学版), 1987, 0(1) |
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| 作者姓名： | 贾宏钧 刘馨 严幼芳 叶雨文 |
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| 作者单位： | 湖南医学院药理学教研室(贾宏钧，刘馨，严幼芳)，湖南医学院药理学教研室(叶雨文) |
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| 摘 要： | 在不同实验动物模型上,丙戊酸钠抗氯化钡性大鼠心律失常作用明显强于奎尼丁和利多卡因等,与心得安相当;抗肾上腺素性豚鼠心律失常作用,与异搏定相当,提高家兔电室颤阈值的作用大于心得安,但比利多卡因弱;对大鼠坐骨神经的局部麻醉作用弱于奎尼丁。本品的抗心律失常作用与自主神经活动无关;对心率影响小;对乙酰胆碱性狗心房颤动无效,
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| 关 键 词： | 丙戊酸盐 普诺洛尔(心得安) 维拉帕米(异搏定) 利多卡因 奎尼丁 苯妥英 抗心律失常剂 药物作用 对比研究 大鼠 豚鼠 狗 疾病模型 动物 |
COMPARISON OF THE ANTIARRHYTHMIC ACTIVITY OF SODIUM VALPROATE AND CLASSICAL ANTIARRHYTHMIC DRUGS IN ANIMALS |
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| Jia Hongjun,Liu Xin,Yan Youfang,Ye Yuwen. COMPARISON OF THE ANTIARRHYTHMIC ACTIVITY OF SODIUM VALPROATE AND CLASSICAL ANTIARRHYTHMIC DRUGS IN ANIMALS[J]. Journal of Central South University. Medical sciences, 1987, 0(1) |
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| Authors: | Jia Hongjun Liu Xin Yan Youfang Ye Yuwen |
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| Affiliation: | Jia Hongjun,Liu Xin,Yan Youfang,Ye Yuwen Department of Pharmacology,Hunan Medical College |
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| Abstract: | The LD_(50)of sodium valproate(VPA),propranolol(PRO),verapamil(VRP),lidocaine(LDC),quinidine(QND)and sodium phenytoin given to mice intrave-nosly was determined.The antiarrhythmic action of these drugs on several modelswas compared at the equitoxic doses(the same fractions of LD_(50)).The action ofVPA against the arrhythmia induced by iv BaCl_2 was similar to that of PRO butstronger than that of QND and LDC in anesthetized rats.The effects of VPA onarrhythmia induced by iv adrenalin were similar to that of VRP in anesthetizedguinea pigs.The activity of VPA to raise electrical ventricular fibrillationthresholds was stronger than that of PRO and less effective than that of LDC inanesthetized rabbits.VPA was ineffective in prevention of atrium fibrillationinduced by topical application of acetylcholine on right atrium in anesthetizeddogs,and it produced less local anesthesia on the sciatic nerves than that of QNDin rats.Antiarrhythmic effect of VPA was not influenced by activity of theautonomic nerve system. |
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| Keywords: | Valproate Propranolol Verapamil Lidocaine Quinidine Phenytoin Antiarrhythmic agents Drug effects Comparativestudy Rats Guinea pigs Dogs Disease models animal |
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