四联疗法和三联疗法治疗十二指肠溃疡的疗效比较

目的对比含呋喃唑酮及胶体果胶铋的四联疗法和经典三联疗法对十二指肠溃疡(DU)幽门螺杆菌感染(HP)初治者的疗效。方法选择有HP感染的十二指肠溃疡(DU)患者86例,随机均分为治疗组和对照组。治疗组选择埃索美拉唑+阿莫西林+呋喃唑酮+胶体果胶铋四联疗法,疗程10d;对照组选择埃索美拉唑+阿莫西林+克拉霉素经典三联疗法,疗程10d。观察HP的根除率和不良反应情况。结果含呋喃唑酮及胶体果胶铋的四联疗法与经典三联疗法的HP根除率分别为90.1%、79.1%,差异有显著性(P<0.05)。十二指肠溃疡治疗总有效率差异无显著性(P>0.05)。结论含呋喃唑酮及胶体果胶铋的四联疗法根除幽门螺杆菌感染安全、有效。

Clinical Effects of Quadruple and Triple Chemotherapy for the Treatment with Duodenal Ulcer

Objective Clinical Study Comparison the effects of Furaxone and Pectin Bismuth-based quadruple chemotherapy and triple chemotherapy for the treatment eradication of helicobacter pylori （HP） in patients with duodenal ulcer. Methods 86 patients with HP infection accompanied with duodenal ulcer were randomly divided into treatment group and control group. The patients in treatment group were given Esomeprazole, Amoxicillin, Furaxone and Pectin Bismuth for 10 days, while in control group received Esomeprazole, Amoxicillin and Clarithromycin. The condition of HP eradication and side-effects were erahuated. Results The two therapies were effective and safe. The eradication rates of HP in treatment group were significantly higher than that in control group （90.1% vs 79.1%）, （P〈0.05）. The total effective rate in patients with duodenal ulcer were no significant difference （P〉0.05）. Conclusion The quadruple therapy of Esomeprazole, Amoxicillin, Furaxone and Pectin Bismuth is a safe and effective choice for HP eradication.