高血压患者血管内皮细胞合成分泌一氧化氮功能的研究

目的　了解高血压与血管内皮细胞合成分泌ＮＯ功能改变的情况。方法　采用肢体缺血再灌的方法，刺激血管内皮细胞合成分泌ＮＯ，检测血中亚硝酸盐浓度变化情况。结果　发现基础状态下高血压患者合成分泌ＮＯ功能较正常血压者高（Ｐ＝０－０２） ，而刺激状态下合成分泌功能则较正常血压者低（ Ｐ＝ ０－００５）。结论　高血压患者长期ＮＯ合成分泌功能亢进，造成应激能力下降，可能是造成高血压发生发展的原因之一。

The study on vascular endothelial function about nitric oxide generation and release in essential hypertensive patients

Objective To study the relationship between essential hypertension and vascular endothelial function about nitric oxide generation and relese.Methods To measure nitric concentration changed in plasma before/after reactive hyperemia.Results Endothelial function was higher in essential hypertensive patients than in normotensive patients ( P =0 002). But reactive hyperemia induced nitrite changing in EH patients was Smaller than in NT Subject ( P =0 005). Conclusions It seemed that induced generation and release of nitric oxide from endothelial calls in EH patient was lower than NT subject. Maybe it was the cause of essential hypertension.