不同方式营养支持对重症急性胰腺炎患者血浆内毒素水平的影响

目的]探讨不同方式营养支持对重症急性胰腺炎患者血浆内毒素水平的影响。方法]采用单纯随机抽样方法将符合入选标准的47例重症急性胰腺炎患者随机分为肠内营养联合肠外营养组(PN+EN组,n=24)和完全肠外营养(TPN组,n=23)。两组病人接受同样的基础治疗,所有病人均于营养支持前及营养支持后d3、d7、d10检测血浆内毒素(LPS)浓度,并观察并发症发生情况。结果EN+PN组治疗后血浆内毒素水平较治疗前逐渐降低,而TPN组较治疗前逐渐增高。治疗d7和d10EN+PN组显著低于TPN组,且差异有统计学意义(P﹤0.01)。PN+EN组的并发症发生率低于TPN组,且腹胀和腹泻发生率显著降低(P﹤0.05)。结论]早期肠内营养可维持肠道黏膜屏障功能,显著降低SAP患者血浆LPS浓度,减少并发症发生。

EFFECT OF DIFFERENT NUTRITION SUPPORT ON THE PLASMA LIPOPOLYSACCHARIDE IN THE PATIENTS WITH SERVE ACUTE PANCREATITIS

Objective] To determine the effect of different nutrition support on the concentration of plasma lipopolysaccharide (LPS) of the patients with severe acute pancreatitis. Methods] Forty-seven patients were randomly divided into enteral nutrition and parenteral nutrition (PN+EN) group (n=24) and total parenteral nutrition (TPN) group (n=23) .All the patients received the same base therapy and their plasma LPS were checked before the treatment and on the third, the seventh, the tenth day after the treatment ...