早期盐酸纳洛酮治疗重型颅脑损伤的临床疗效分析

目的分析早期大剂量应用纳络酮治疗重型颅脑损伤的临床疗效。方法将66例重型颅脑损伤患者分为治疗组及对照组，纳洛酮治疗组33例，常规对照组33例。治疗组均在常规治疗的基础上早期采用大剂量持续给予纳络酮，对照组按照常规治疗方法进行治疗，观察患者生命体征、颅内压、CT征变化、外伤后脑血管痉挛发生率和远期疗效等，并对数据进行统计学处理。结果纳络酮治疗组的近、远期疗效均较对照组有显著改善（P〈0．05）。结论早期大剂量应用纳络酮可以减轻脑水肿，缩短昏迷时间，早期使用大剂量纳洛酮可明显降低急性重型颅脑损伤致残、死亡率，在促使脑功能恢复，改善生活质量和预后方面的确有效。

Analysis of clinical efficacy on patients with severe brain injury administrated with high-dose naloxone at the early stage

Objective To investigate the influence of gestational diabetes mellitus(GDM) on maternal and neonatal prognosis. Methods Clinical data of 42 cases of GDM (GDM group)and 120 cases without any complication (control group)were analyzed retrospectively. Pregnancy outcome, pregnancy complication and neo-natal outcome were compared in two groups. Results Caesareansection rate in control group and GDM group were 60.0% and 93.5% respectively, with operative indication were 18.3% and 51.6%. Incidence rate of pre-mature delivery were 9.2% and 22.6% and incidence rate of macrosomia were 6.7% and 19.4% respectively. There were statistical differences between two groups. Conclusion Caesareansection rate,incidence rate of pre-mature delivery and incidence rate of macrosomia in gravid women of GDM are all higher than normal gravid women. We should pay closely attention to GDM gravid women. Maternal and neonatal complication can be de-creased if we perform screening GDM and dealing with in early stage.