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| 全脑缺血再灌注大鼠血液内源性H_2S的动态变化 | |
| 引用本文： | 黄琬璐,杜爱林,姜洪波,任彩丽,李文东,李东亮,赵红岗. 全脑缺血再灌注大鼠血液内源性H_2S的动态变化[J]. 河南职工医学院学报, 2010, 22(5): 521-523 |
| 作者姓名： | 黄琬璐 杜爱林 姜洪波 任彩丽 李文东 李东亮 赵红岗 |
| 作者单位： | 1. 新乡医学院,基础医学院 2. 新乡医学院基础医学院,生理学教研室 3. 新乡医学院,第三附属医院 4. 新乡医学院,三全学院,河南,新乡,453003 |
| 基金项目： | 新乡医学院大学生科研基金项目，新乡医学院高学历人才科研启动项目，省教育厅课题 |
| 摘 要： | 目的研究大鼠全脑缺血再灌注过程中,血浆中内源性硫化氢（H2S）的动态变化。方法12只SD大鼠采用断尾取血法取血0.3~0.4 ml。在每只大鼠正常时、凝闭6 h,I/R 6 h、I/R 12 h、I/R 24 h、I/R 48 h、I/R 72 h时7个时间点测定大鼠血液中H2S的含量。结果和正常组大鼠比较,凝闭6 h组I/R 6 h组血浆中H2S含量明显升高,有显著差异（P〈0.05）;I/R 12 h组大鼠和正常组大鼠比较,血浆H2S含量无显著差异（P〉0.05）;I/R 24 h组大鼠和正常组大鼠比较,血浆H2S含量明显降低,有显著差异（P〈0.01）;I/R 48 h组和I/R 72 h组大鼠与正常组大鼠比较,血浆H2S含量明显升高,有极显著差异（P〈0.05）。结论内源性H2S在全脑缺血再灌注过程中呈动态变化,可能在缺血再灌注早期发挥作用。 |
| 关 键 词： | 全脑缺血再灌注 硫化氢 大鼠 |
Dynamic Changes of Endogenous H2S in Rats with Global Cerebral Ischemia Reperfusion |
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| Affiliation: | HUANG Wan-lu,DU Ai-lin,JIANG Hong-bo,et al(Xinxiang Medical College,Xinxiang Henan 453003,China) |
| Abstract: | Objective To study the dynamic changes of endogenous H2S in rats with global cerebral ischemia reperfusion. Methods 0.3～0.4 ml blood were taken from 12 SD rats by docking meths.H2S in blood of all rats were determined at 7 time points（normal,setting closed 6 hours,I/R 6 hours.I/R 12 hours,I/R 24 hours,I/R 48 hours and I/R 72 hours）.Results H2S in blood was increased significantly at the point time of setting closed 6 hours,I/R 6 hours,I/R 48 hours and I/R 72 hours,but it had no significantly changes at I/R 12 hours.It was decreased significantly at the time point of I/R 24 hours,compared with that of normal group.Conclusion Endogenous H2S in rats with global cerebral ischemia reperfusion has a dynamic change.It may play a role at the early time of ischemia reperfusion. |
| Keywords: | global cerebral ischemia reperfusion H2S rat |
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