扶正益气汤辅助化疗对大肠癌术后患者的影响

目的:观察扶正益气汤辅助化疗对大肠癌患者手术后的影响。方法:将本院2009年1月—2011年4月间收治的经术后病理学证实大肠癌的初治住院患者84例,按入院顺序随机分为A、B两组,对照组予FOLFOX化疗方案(奥沙利铂135 mg/m2,第1d用;甲酰四氢叶酸200 mg/m2·d,5-氟尿嘧啶400 mg/m2·d联用5d静滴,每21天重复1周期),治疗组予FOLFOX化疗方案联合扶正益气汤。2个周期后抽取外周血,测定Treg进行比较,并观察治疗过程中的毒副反应,根据治疗前后Karuafsry计分值做生活质量评价。结果:治疗组Treg测定值较对照组面明显降低,毒副反应明显减少,生活质量明显提高,P<0.05,有显著意义。结论:扶正益气汤辅助化疗可提高患者术后免疫功能,增强化疗效果,不但起到联合抗肿瘤作用,还能降低化疗药物毒副作用,提高生活质量。

Effect of Chemotherapy Assisted with Fuzheng Yiqi Decoction for Colorectal Cancer Patients after Operation

Objective：To investigate the effect of chemotherapy assisted with Fuzheng Yiqi Decoction for colorectal cancer pa tients after operation. Methods ： Eightyfour cases of colorectal cancer patients, who were pathologically confirmed after operation and treated in our hospital from January 2009 to April 2011, were randomly divided into two groups. Control group was treated with FOLFOX chemotherapy oxaliplatin, 135 mg/（ m2 . d） , 1 d ; folinic acid 200 rag/（ m2 . d） , 5 FU400 mg/（ m2 . d） , combined with intravenous infusion 5 d ,repeated 21 days for 1 cycles]. Treatment group was treated with FOLFOX chemotherapy combined with Fuzheng Yiqi Decoction. Extracting peripheral blood after 2 cycles, the Treg was detected and compared. The adverse reaction during treatment was observed. According to the Karuafsry score before and after treatment was used to evaluate the quality of pa tients＇life. Results：The Treg values in treatment group were markedly lower, toxicity was significantly reduced, and quality of life was improved. Compared with the control group, there was significant difference, P 〈 0. 05. Conclusion ： Chemotherapy assisted with Fuzheng Yiqi Decoction could improve the immune function of patients, enhance chemotherapy effect, not only enhance anti tumor effect, but also reduce the toxic side effects of chemotherapy, and improve the quality of patients life.