超微舒胸胶囊对血瘀大鼠血液黏度及纤溶系统的影响

目的:研究舒胸胶囊微粉活血化瘀作用机理。方法:采用肾上腺素加冰浴的方法复制急性血瘀模型,观察舒胸胶囊微粉对大鼠血瘀模型全血黏度、血浆组织型纤溶酶原激活物(T-PA)及其抑制物(PAI)的变化,并与舒胸胶囊进行比较。结果:舒胸胶囊微粉能显著降低大鼠血瘀模型的全血黏度和血浆PAI含量,升高血浆T-PA含量;舒胸胶囊微粉低剂量组与舒胸胶囊高剂量组相比无显著性差异,高剂量组疗效明显优于舒胸胶囊高剂量组。结论:舒胸胶囊微粉具有明显的活血化瘀作用,其作用机制可能与改善血液流变性和纤溶系统活性有关。

Effects of Shuxiong Capsule Micropowder on Whole Blood Viscosity and Activity of Fibrinolytic System of Rats with Acute Blood Stasis

Objective ： To investigate the effect mechanism of Shuxiong Capsule Micropowder on promoting blood circulation to resolve stasis. Methods ： Rat acute blood stasis models were replicated by means of epinephrine in ice - bath, change of whole blood viscosity, the tissue activator of plasminogen activator activity （ T - PA） , plasminogen activator inhibitor activity （ PAI ） were observed respectively, and contrasted with Shuxiong Capsule. Results ： Shuxiong Capsule Micropowder can significantly decrease whole blood viscosity and p｜asminogen activator I inhibitor activity ,and increase the tissue activator of plasminogen activator activity. There was no statistical difference between low dose group of Shuxiong Capsule Micropowder and high dose group of Shuxiong Capsule. The effect of high dose group of Shuxiong Capsule Micropowder is superior to high dose group of Shuxiong Capsule. Conclusion ： The results stated that Shuxiong Capsule Micropowder has remarkable function of activating blood circulation and eliminating stasis by improving hemorrheology and fibronolysis.