应用聚合酶链反应对心血管疾病患者血清肺炎衣原体DNA的检测及意义

目的　了解肺炎衣原体(TWAR)与心脏病的相关性,多方面探讨冠心病的发病因素。方法　采用聚合酶链反应(PCR)法,对冠心病100例,高血压病40例,心肌疾病40例,心律失常40例,正常对照60例,血清TWARDNA进行检测。结果　不同组别间TWAR阳性率的差别有高度显著性(χ

Detection of Serum TWARDNA of Patients with Cardio Vascular Disease by PCR

Objective To investigate the relationship between cla-mydiapneumoniae and cardiovascular disease.Methods By us i ng PCR,the authors detected the serum TWAR DNA in patients with coronary heart d iease,hepertension,cardiomyopathy,arrhythmia,and normal control.Results Significant difference was observed in positive rate of serum TWAR DNA among patients with coronary heart disease,hypertension,cardiomyopathy,arrhythm ia and normal control(χ2＝30.52,P＜0.05).The positive rat es o f TWAR in patients with coronary heart disease(31.0%),cardiomyopatyhy(32.5%),hep ertension(7.5%),arrhythmia(12.5%),normal control(1.67%),Prompted the Positive ra tes of TWAR DNA in patients with coronary heart disease and cardiomyopathy were higher than those of patients with hypertension,arrhythmia and normal control.[ WTHZ Conclusions The positive rates of serum TWAR DNA in patients with coronary heart disease and cardiopathy were high compared to those with hyperte nsion,arrhythmia and normal control.The results of this study suggested that cla -mydia pneumoniae might be one of the causes of coronary heart disease and card iopathy.