表皮生长因子受体在肺癌组织中的表达

目的　探讨肺癌组织中表皮生长因子受体 (EGFR)的表达水平及其临床意义。方法　采用免疫组化ABC法检测 3 9例肺良性疾病、95例原发性肺癌及癌旁肺组织中EGFR的表达水平。结果　非小细胞肺癌 (NSCLC)组织EGFR表达阳性率为 87.9% ( 80 / 91) ,肺良性病变肺组织为 10 .3 % ( 4/3 9) ,4例小细胞肺癌 (SCLC)无EGFR表达。在NSCLC中 ,距癌组织 3cm以内癌旁肺组织EGFR阳性率为6 3 .7% ( 5 8/ 91) ,6cm以远正常肺组织为 12 .1% ( 11/ 91)。结论　肺癌组织EGFR表达水平显著高于良性疾病肺组织 ,检测EGFR表达有助于肺部良恶性疾患的鉴别诊断。

Expression of EGFR in human lung cancer tissues

Objective To determine the expression of EGFR of lung cancer tissues and its clinical significance.Methods The expression of EGFR was detected in 95 primary lung cancer tissues and their para cancerous lung tissues and 39 benign pulmonary lesion tissues as control by immunohistochemical method.Results The positive rate of EGFR expression was 87.9%(80/91) in non small cell lung cancer (NSCLC) and 10.3%(4/39) in benign pulmonary tissues, but was 0% in 4 small cell lung cancer. The positive rate was 63.7%(58/91) in the paracancerous tissues from 0 to 3.0 cm outside the tumors,12.1%(11/91) from 3.0 to 6.0cm outside the tumors. Conclusion The positive rate of EGFR expression in lung cancer tissues was significantly higher than that in benign pulmonary tissues. Determinatation of EGFR expression might be useful to differentiate malignant from benign lesion of the lung.