哮喘及肺原性心脏病急性加重期血浆降钙素基因相关肽及内皮素-1含量变化

目的：探讨神经肽——降钙素基因相关肽（ＣＧＲＰ）和内皮素１（ＥＴ１）在哮喘及肺心病急性加重期中的作用。方法：用放射免疫分析法对哮喘及肺原性心脏病（肺心病）急性加重期患者血浆ＣＧＲＰ和ＥＴ１含量进行检测。结果：哮喘发作期患者血浆ＣＧＲＰ及ＥＴ１含量均较缓解期及正常人显著增高；肺心病急性加重期患者血浆ＣＧＲＰ和ＥＴ１含量亦较正常人及慢性阻塞性肺病（ＣＯＰＤ）患者显著增高；呼吸衰竭（呼衰）时血浆ＣＧＲＰ及ＥＴ１水平较非呼衰组均明显增高；随心力衰竭、缺氧及二氧化碳潴留程度的加重，血浆ＣＧＲＰ及ＥＴ１水平有增高趋势；综合治疗可使ＣＯＰＤ患者血浆ＣＧＲＰ和ＥＴ１水平降低。结论：ＣＧＲＰ和ＥＴ１是参与哮喘、肺心病及ＣＯＰＤ病理生理过程的重要神经肽，其血浆水平高低与病情轻重密切相关，可作为反映病情及预后、判断疗效的参考指标。

Changes of plasma calcitonin generelated peptide and endothelin1 levels in asthma and cor pulmonale patients with acute exacerbation/

bjective:To investigate the role of neuropeptide in the pathogenesis of asthma and cor pulmonale patients with acute exacerbation.Methods:Plasma calcitonin generelated peptide (CGRP) and endothelin1 (ET1) levels were measured by using radioimmunoassay in asthma and cor pulmonale patients with acute exacerbation.Results:Plasma CGRP and ET1 levels in asthma attacks were highly elevated compared to those in stable stage and normal controls.Both plasma CGRP and ET1 levels in cor pulmonale patients of severe stage were higher than that in patients with chronic obstructive pulmonary disease (COPD) and normal controls;Also,patients with respiratory failure had higher plasma CGRP and ET1 levels than that of nonrespiratory failure group.Plasma CGRP and ET1 levels were poraled with the degree of heart failure,hypoxemia and hypercapnia.Plasma CGRP and ET1 levels were decreased slighly in COPD patients after treatment.Conclusions:Both CGRP and ET1 are important neuropeptids in the pathogenesis of asthma,cor pulmonale and COPD.Plasma CGRP and ET1 levels are associated with the disease severity,and may serve as useful markers to reflect disease conditions as well as prognosis.