新型人工骨修复材料在骨缺损修复中的临床研究

目的 探讨新型人工骨修复材料和羟基磷灰石生物陶瓷在骨缺损修复中的临床效果,并评估新型人工骨修复材料的有效性和安全性.方法 选取2019年12月至2021年4月中国人民解放军联勤保障部队第九二○医院收治的50例骨缺损并接受骨缺损重建修复术患者,采用随机单盲法,分为新型人工骨修复材料组(实验组)和羟基磷灰石生物陶瓷组(对照...

Clinical study of new artificial bone repair materials in bone defect repair

Objective To investigate the effects of artificial bone repair materials and hydroxyapatite bioceramics on the repair of bone defects and to evaluate the effectiveness and safety of artificial bone repair materials. Methods A total of 50 patients with bone defects treated in the 920 Hospital of Joint Logistics Support Force of Chinese People''s Liberation Army from December 2019 to April 2021 were randomly divided into new artificial bone repair group (n=25) and hydroxyapatite bioceramic group (n=25). The bone graft fusion rates of the two groups were observed and compared at 1 week, 6 weeks, 12 weeks and 24 weeks after operation. and the changes of blood routine, neutrophil percentage, C-reactive protein, ESR, creatinine, glutamic pyruvic transaminase and glutamic oxaloacetic transaminase before and 1 week after operation were recorded. Results After operation, the vital signs of 46 patients were stable, the incisions healed in the first stage, and no adverse events occurred. There was no significant difference in the number of bone graft fusion between the two groups at 1 week, 6 weeks, 12 weeks and 24 weeks after operation, but the white blood cell count (WBC) and the percentage of neutrophils (NEU) increased significantly between the two groups, especially in the hydroxyapatite biological ceramic group. There was no significant difference in the results of glutamic pyruvic transaminase (ALT) and aspartate oxaloacetic transaminase (AST) between the two groups, and the serum creatinine in the experimental group decreased significantly after operation, but there was no significant difference between the two groups. Conclusion The new artificial bone repair materials and hydroxyapatite bioceramics showed good clinical effect in the repair of bone defect of four limbs. Therefore, the new artificial bone repair materials can be used as a good substitute for hydroxyapatite bioceramics in the treatment of limb bone defects.