磷酸钙人工骨修复骨缺损的研究进展

继发于各类病因的大段骨缺损通常需要人工骨材料进行修复，目前常用的人工骨材料包括磷酸钙和硫酸钙基人工骨、生物活性玻璃等，以磷酸钙为主要成分的人工骨，复合其他一种或多种材料以期改善人工骨的性能是目前的研究热点。本文将总结以磷酸钙为基质的各类复合材料，包括与聚合物复合的磷酸钙材料、以磷酸钙为基质的合金材料、药物缓释材料以及骨组织工程材料在骨缺损修复中的研究进展，为以磷酸钙为基质新材料的研究奠定基础。

Progress of calcium phosphate artificial bone in repairing bone defect

Large bone defects secondary to various causes usually need to repair with artificial bone materials, the commonly used artificial bone materials include artificial bone-based calcium phosphate and calcium sulfate substrate, bioactive glass and so on. The artificial bones with calcium phosphate as the main component, combined with one or more other materials in order to improve the performance of artificial bones has become a hot topic in current research. In this paper, we will summarize the research progress of various kinds of composites with based calcium phosphate substrate in bone defect repair, including composite with polymer, alloy material, drug sustained release and bone tissue engineering material, to provide the basis for the related research of calcium phosphate artificial bone.