2017—2019年贵阳市吸毒人群HCV感染相关因素及HIV、梅毒感染状况

 目的 分析贵阳市哨点吸毒人群丙型肝炎病毒（HCV）、人类免疫缺陷病毒（HIV）与梅毒感染状况，并分析HCV感染相关影响因素，为针对性地预防控制吸毒人群感染HCV提供依据。方法 采用重复横断面调查方法调查贵阳市2017—2019年吸毒哨点监测的吸毒人群，每年前往不同的戒毒场所， 以4—7月为监测期，同时采集静脉血进行HIV、梅毒及HCV抗体检测。比较分析不同因素间HCV感染率。结果 2017—2019年共调查 1 186例吸毒者，各年份HIV感染率分别为0.8%、0.2%及0.5%，梅毒感染率分别为7.1%、8.9%及9.3%，HCV感染率分别为40.9%、46.4%及46.3%。年龄≥25岁（OR=3.334~5.963）、女性（OR=1.487）、共用注射器具（OR=8.107）、最近一个月注射毒品（OR=6.300）及梅毒抗体阳性（OR=1.514）是吸毒人群感染HCV的危险因素。结论 近年来贵阳市吸毒人群HIV感染率较低，但HCV感染率较高，流行形势严峻，应针对吸毒人群HCV的相关影响因素加强综合防治。

HCV infection-related factors as well as HIV and syphilis infection status among drug users in Guiyang City from 2017 to 2019

Objective To analyze the infection status of hepatitis C virus (HCV), human immunodeficiency virus (HIV) and syphilis among drug users in sentinel surveillance in Guiyang City, analyze the related influencing factors of HCV infection, so as to provide basis for targeted prevention and control of HCV infection among drug users. Methods Repeated cross-sectional survey was conducted among drug users in sentinel surveillance in Guiyang City from 2017 to 2019, different drug rehabilitation centers were surveyed each year, monitoring period was from April to July, venous blood was collected for detection of HIV, syphilis and HCV antibody. Infection rates of HCV due to different factors were compared and analyzed. Results From 2017 to 2019, a total of 1 186 drug users were surveyed, HIV infection rates in each year were 0.8%, 0.2% and 0.5% respectively, syphilis infection rates were 7.1%, 8.9% and 9.3% respectively, HCV infection rates were 40.9%, 46.4% and 46.3% respectively. Age ≥ 25 years old (OR=3.334-5.963), female (OR=1.487), sharing injection device (OR=8.107), injecting drugs in recent one month (OR=6.300) and positive syphilis antibody (OR=1.514) were risk factors for HCV infection in drug users. Conclusion In recent years, HIV infection rate among drug users in Guiyang City is low, but HCV infection rate is high, epidemic situation is severe, comprehensive prevention and treatment should be strengthened according to the related influencing factors for HCV in drug users.