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Design and inhibitory properties of synthetic Bowman-Birk loops |
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| Authors: | DENNIS L. MAEDER MARGARET SUNDE DAWIE P. BOTES |
| Abstract: | A cyclic tridecapeptide based on the sequence of an anti-tryptic loop of a Bowman-Birk inhibitor was synthesized, and demonstrated to be active as an inhibitor of trypsin. Molecular modeling of this sequence suggested an improved sequence which demonstrated an order of magnitude improvement in the inhibitory constant. |
| Keywords: | Bowman-Birk inhibitor kinetic macrotyloma model peptide synthesis |