| Abstract: | Transgenic mice technology in conjunction with other molecular biological and embryo manipulation techniques has made it possible to manipulate the mouse genome to elucidate the molecular mechanisms of normal and abnormal embryonic development. This genetic technology also permits the isolation of novel genes involved in developmental events. It has and certainly will greatly contribute to the better understanding of the pathogenesis of congenital anomalies. However, the majority of congenital anomalies in humans occur from multifactorial causes including not only genetic but also various environmental factors. Thus, transgenic mice can be utilized as an excellent genetic tool on which all the available conventional teratological techniques and informations are concentrated to elucidate molecular mechanisms and the holistic picture of congenital anomaly formation. |
