高毒力肺炎克雷伯菌毒力和耐药机制研究进展

自20世纪80年代中期以来，高毒力肺炎克雷伯菌（hvKp）感染率逐年增加，已引起全球的关注。hvKp较普通型肺炎克雷伯菌（cKp）更具致病性，在健康人群中即可引发侵袭性感染，不仅病死率高（3%~31%），而且常伴随严重的后遗症，如眼盲或神经系统疾病。更令人担忧的是，近年来对第三代头孢菌素、碳青霉烯类抗生素和粘菌素耐药的hvKp菌株相继出现，给临床治疗和管理工作带来巨大挑战。因此，了解hvKp毒力及耐药机制尤为重要，此文就其最新研究进展进行综述。

Research progress on virulence and drug resistance mechanism of hypervi-rulent Klebsiella pneumoniae

Since the mid-1980s, incidence of hypervirulent Klebsiella pneumoniae (hvKp) has increased year by year, which has attracted global attention. hvKp is more pathogenic than classic Klebsiella pneumoniae (cKp), it can lead to invasive infection in healthy people, not only with high mortality (3%-31%), but also often accompanied by serious sequelae, such as blindness or neurological diseases. What is more worrying is that, in recent years, the emergence of hvKp strains resistant to the third generation cephalosporins, carbapenem antibiotics and colistin has brought great challenge to clinical treatment and management. Therefore, understanding virulence and drug resis-tance mechanism of hvKp is particularly important, this paper reviews the latest research progress of hvKp.