沙粒病毒科烈性病毒研究领域的文献计量和知识图谱分析

目的 为全面了解国际沙粒病毒科烈性传染病病毒领域研究现状及态势,为本国新发和烈性传染病防控及生物安全提供情报参考。方法 利用文献计量法和科学知识图谱分析方法,以本国《人间传染的病原微生物名录》规定的危害程度为第一类的8种沙粒病毒科烈性传染病病毒为研究对象,进行热点和趋势分析。结果 共采集到8种沙粒病毒科烈性病毒领域的相关文献1 840篇,其中对拉沙热病毒研究的文献最多,达1 243篇。国际上对沙粒病毒科烈性传染病病毒研究始于20世纪60年代,美国、阿根廷、德国等在该领域参与度很高,发表相关文献数分别为892、387、186篇,本国在该领域的研究论文共33篇,排名第13;研究机构发表相关文献数居前三位的分别是美国国立卫生研究院、阿根廷布宜诺斯艾利斯大学、美国疾病控制与预防中心,分别发表237、229、164篇。该领域研究方向和热点主要有：病毒流行病学和生物安全问题,病毒遗传及致病机制,病毒治疗,病毒药物、疫苗研发以及病毒快速检测技术。结论 沙粒病毒科烈性传染病在本国发生较少,但世界尤其是西方发达国家对该科病毒高度关注,本国对该领域的研究较落后,需加强相关研究以防范疫情及潜在的国家生物安全风险。

Bibliometrics and knowledge mapping analysis on high pathogenic viruses in Arenaviridae family

Objective To comprehensively understand the research status and trend of fulminating infectious di-seases(FIDs) virus of world Arenaviridae family, provide information and reference for the prevention and control as well as biosafety of emerging infectious diseases and FIDs in China. Methods Using bibliometrics and scientific knowledge map analysis method, 8 kinds of FIDs virus of Arenaviridae classified as the first category according to hazard degree in the list of Pathogenic microorganisms of human infection were selected as the research objects for hot spot and trend analysis. Results A total of 1 840 articles in the field of 8 kinds of FIDs virus of Arenaviridae were collected, 1 243 of which were about Lassa fever virus. The international research on FIDs virus of Arenaviridae began in 1960s, the United States, Argentina and Germany have highly participated in this field, with 892, 387 and 186 articles published respectively, there are 33 domestic research articles in this field, ranking the 13th; the top three research institutions which published related literatures were National Institutes of Health of the United Status, University of Buenos Aires of Argentina, as well as Centers for Disease Control and Prevention of the United Status, with 237, 229 and 164 articles published respectively. The research directions and hot spots in this field mainly include:viral epidemiology and biosafety, virus genetics and pathogenesis, anti-viral treatment, anti-viral drugs, vaccine development, and rapid detection technology of viruses. Conclusion Occurrence of FIDs caused by Arenaviridae viruses are less in China, but in the world, especially the western developed countries, close attention has been paid to it, China is still lagging behind in this field, it is necessary to strengthen relevant research to prevent the epidemic and potential national biosafety risks.